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GTF2A1 - general transcription factor IIA subunit 1 Gene

Also Known as TF2A1; TFIIA; TFIIAL; TFIIA-42

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2957

About GTF2A1

Cytogenetic location: 14q31.1 Genomic coordinates (GRCh38): 14:81,175,452-81,221,390 (from NCBI)

This gene has 4 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 15.3), testis (RPKM 12.9) and 25 other tissues.

Summary

Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]

GTF2A1 Products (3)

mRNA	Protein	Name
NM_001278940.2	NP_001265869.1	transcription initiation factor IIA subunit 1 isoform 3
NM_015859.4	NP_056943.1	transcription initiation factor IIA subunit 1 isoform 1
NM_201595.3	NP_963889.1	transcription initiation factor IIA subunit 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7724559	GOA
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	29111974	GOA
enables RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	27193682	GOA
enables RNA polymerase II general transcription initiation factor binding	IPI IPI: Inferred from physical interaction	8626665	GOA
enables TBP-class protein binding	IPI IPI: Inferred from physical interaction	7724559	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8006019	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	8626665	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10022900	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	11030333	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7724559	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	10022900	GOA
part of transcription factor TFIIA complex	IDA IDA: Inferred from direct assay	7724559	GOA
part of transcription factor TFIIA complex	IPI IPI: Inferred from physical interaction	8626665	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	27193682	GOA
part of transcription preinitiation complex	IDA IDA: Inferred from direct assay	8224850	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF2A1 Protein Structure

TFIIA

0
100
200
300
376 a.a.

Protein Preferred Names	Protein Names
transcription initiation factor IIA subunit 1	TFIIA alpha/beta subunits

GTF2A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GTF2A1	P52655	SP4	Homo sapiens	Q02446	Validated Y2H	32296183
Intra	GTF2A1	P52655	SP4	Homo sapiens	Q02446	Y2H Prey Pooling	32296183
Intra	GTF2A1	P52655	SP4	Homo sapiens	Q02446	Y2H Array	32296183
Intra	GTF2A1	P52655	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	GTF2A1	P52655	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	GTF2A1	P52655	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	GTF2A1	P52655	GTF2A2	Homo sapiens	P52657	Anti Tag CoIP	28514442
Intra	GTF2A1	P52655	GTF2A2	Homo sapiens	P52657	Pull Down	8626665
Intra	GTF2A1	P52655	GTF2A2	Homo sapiens	P52657	Y2H Prey Pooling	25416956
Intra	GTF2A1	P52655	GTF2A2	Homo sapiens	P52657	Validated Y2H	32296183
Intra	GTF2A1	P52655	GTF2A2	Homo sapiens	P52657	Y2H Prey Pooling	32296183
Intra	GTF2A1	P52655	GTF2A2	Homo sapiens	P52657	Y2H Array	32296183
Intra	GTF2A1	P52655	GTF2A2	Homo sapiens	P52657	Y2H Array	25416956
Intra	GTF2A1	P52655	NFYA	Homo sapiens	P23511-2	Y2H Array	32296183
Intra	GTF2A1	P52655	NFYA	Homo sapiens	P23511-2	Y2H Prey Pooling	32296183
Intra	GTF2A1	P52655	PRR20D	Homo sapiens	P86480	Validated Y2H	32296183
Intra	GTF2A1	P52655	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	GTF2A1	P52655	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	GTF2A1	P52655	ERN1	Homo sapiens	O75460-2	Validated Y2H	32814053
Intra	GTF2A1	P52655	ERN1	Homo sapiens	O75460-2	Y2H Array	32814053
Intra	GTF2A1	P52655	ERN1	Homo sapiens	O75460-2	Y2H Pooling	32814053
Intra	GTF2A1	P52655	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	GTF2A1	P52655	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	GTF2A1	P52655	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	GTF2A1	P52655	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	GTF2A1	P52655	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	GTF2A1	P52655	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	GTF2A1	P52655	TBP	Homo sapiens	P20226	Anti Tag CoIP	33961781
Intra	GTF2A1	P52655	TBP	Homo sapiens	P20226	Anti Tag CoIP	28514442
Intra	GTF2A1	P52655	PSMC6	Homo sapiens	P62333	Validated Y2H	32296183
Intra	GTF2A1	P52655	PSMC6	Homo sapiens	P62333	Y2H Array	32296183
Intra	GTF2A1	P52655	PSMC6	Homo sapiens	P62333	Y2H Prey Pooling	32296183
Intra	GTF2A1	P52655	NFYA	Homo sapiens	P23511	Y2H Prey Pooling	25416956
Intra	GTF2A1	P52655	NFYA	Homo sapiens	P23511	Validated Y2H	25416956
Intra	GTF2A1	P52655	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	GTF2A1	P52655	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	GTF2A1	P52655	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	GTF2A1	P52655	BIRC7	Homo sapiens	Q96CA5	Y2H Prey Pooling	32296183
Intra	GTF2A1	P52655	BIRC7	Homo sapiens	Q96CA5	Validated Y2H	32296183
Intra	GTF2A1	P52655	BIRC7	Homo sapiens	Q96CA5	Y2H Array	32296183
Intra	GTF2A1	P52655	TBPL1	Homo sapiens	P62380	Y2H Array	32296183
Intra	GTF2A1	P52655	TBPL1	Homo sapiens	P62380	Anti Tag CoIP	33961781
Intra	GTF2A1	P52655	TBPL1	Homo sapiens	P62380	Anti Tag CoIP	28514442
Intra	GTF2A1	P52655	TBPL1	Homo sapiens	P62380	Validated Y2H	32296183
Intra	GTF2A1	P52655	TBPL1	Homo sapiens	P62380	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05892	GTF2A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05896	GTF2F1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05898	GTF2H1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05904	GTF2IRD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GTF2A1	MGD	MGI:1933277
Bos taurus	GTF2A1	VGNC	VGNC:29691
Canis familiaris	GTF2A1	VGNC	VGNC:41541
Macaca mulatta	GTF2A1	VGNC	VGNC:73305
Rattus norvegicus	GTF2A1	RGD	RGD:69246
Felis catus	GTF2A1	VGNC	VGNC:104398
Others	GTF2A1	NCBI