2. Gene
  3. GTF2A2 - general transcription factor IIA subunit 2 Gene

GTF2A2 - general transcription factor IIA subunit 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as TF2A2; TFIIA; T18745; TFIIAS; HsT18745; TFIIA-12; TFIIA-gamma

Gene ID: 2958 | Gene type: protein coding

About GTF2A2

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:59,638,062-59,657,515 (from NCBI)

This gene has 10 transcripts (splice variants) and 184 orthologues. Broad expression in testis (RPKM 46.4), colon (RPKM 13.2) and 24 other tissues.

Summary

Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]

GTF2A2 Products(3)

mRNA Protein Name
NM_001320929.2 NP_001307858.1 transcription initiation factor IIA subunit 2
NM_001320930.2 NP_001307859.1 transcription initiation factor IIA subunit 2
NM_004492.3 NP_004483.1 transcription initiation factor IIA subunit 2

GTF2A2 Protein Structure

TFIIA_gamma_N

TFIIA_gamma_N: Transcription initiation factor IIA, gamma subunit, helical domain (1 - 49)

TFIIA_gamma_C

TFIIA_gamma_C: Transcription initiation factor IIA, gamma subunit (51 - 100)

  • 0
  • 100
  • 109 a.a.
Protein Preferred Names Protein Names

transcription initiation factor IIA subunit 2

TFIIA gamma subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05893 GTF2A2 Human Pre-designed siRNA Set A / Unkown
HY-RS05895 GTF2E2 Human Pre-designed siRNA Set A / Unkown
HY-RS05897 GTF2F2 Human Pre-designed siRNA Set A / Unkown
HY-RS05899 GTF2H2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GTF2A2 VGNC VGNC:67492
Bos taurus GTF2A2 VGNC VGNC:29692
Rattus norvegicus GTF2A2 RGD RGD:620720
Macaca mulatta GTF2A2 VGNC VGNC:84345
Canis familiaris GTF2A2 VGNC VGNC:41542
Mus musculus GTF2A2 MGD MGI:1933289