TDGF1 - teratocarcinoma-derived growth factor 1 Gene

Also Known as CR; CR-1; CRGF; CRIPTO

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6997

About TDGF1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,574,535-46,582,457 (from NCBI)

This gene has 5 transcripts (splice variants), 107 orthologues, 5 paralogues and is associated with 7 phenotypes. Biased expression in spleen (RPKM 9.5), kidney (RPKM 5.0) and 5 other tissues.

Summary

This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

TDGF1 Products (2)

mRNA	Protein	Name
NM_001174136.2	NP_001167607.1	teratocarcinoma-derived growth factor 1 isoform 2
NM_003212.4	NP_003203.1	teratocarcinoma-derived growth factor 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables growth factor activity	IDA IDA: Inferred from direct assay	8006041	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12919325	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	11909953	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	17720976	GOA
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	17720976	GOA
involved in cellular response to fibroblast growth factor stimulus	IDA IDA: Inferred from direct assay	17720976	GOA
involved in cellular response to hepatocyte growth factor stimulus	IDA IDA: Inferred from direct assay	17720976	GOA
involved in cellular response to interleukin-6	IDA IDA: Inferred from direct assay	17720976	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	17720976	GOA
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	17720976	GOA
NOT acts upstream of or within epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	8006041	GOA
involved in heart development	IDA IDA: Inferred from direct assay	9576836	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	10493495	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	10493495	GOA
acts upstream of or within positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	9013573	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	9013573	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	12649175	GOA
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	8006041	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	17720976	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10493495	GOA
involved in regulation of signal transduction	IDA IDA: Inferred from direct assay	12649175	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	17720976	GOA
located in cell surface	IDA IDA: Inferred from direct assay	12925698	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	17720976	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	17720976	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TDGF1 Protein Structure

CFC

0
100
188 a.a.

Protein Preferred Names	Protein Names
teratocarcinoma-derived growth factor 1	cripto-1 growth factor

Recombinant TDGF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71112	TDGF1 Protein, Human (HEK293, Fc)	P13385 (L31-S169)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700481	TDGF1 Protein, Human (GST)	P13385 (G32-D150)	≥ 90%, as determined by reducing SDS-PAGE.

TDGF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82500	Cripto1/CRIPTO Antibody (YA2245)	WB, ICC/IF, IP, FC	Human
HY-P85107	Cripto1/CRIPTO Antibody (YA4799)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Microform Holoprosencephaly	Hpe, Minor Form Hpe-L Holoprosencephaly, Minor Form Holoprosencephaly-Like Microform Hpe
Septopreoptic Holoprosencephaly	Septopreoptic Hpe
Midline Interhemispheric Variant Of Holoprosencephaly	Mih Mih Type Hpe Mihf Mihv Middle Interhemispheric Fusion Variant Middle Interhemispheric Variant Of Holoprosencephaly Syntelencephaly
Lobar Holoprosencephaly
Alobar Holoprosencephaly
Semilobar Holoprosencephaly
Teratocarcinoma	Mixed Embryonal Carcinoma And Teratoma
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Charcot-Marie-Tooth Disease, X-Linked Dominant, 6	CMTX6 Charcot-Marie-Tooth Disease X-Linked Dominant 6 Cmt6x X-Linked Charcot-Marie-Tooth Disease Type 6 Charcot-Marie-Tooth Neuropathy, X-Linked Dominant, 6 Charcot-Marie-Tooth Neuropathy X-Linked Dominant 6 Charcot-Marie-Tooth Neuropathy X-Linked 6 Charcot-Marie-Tooth Disease, X-Linked, Type 6
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Germ Cell Cancer	Malignant Germ Cell Tumor Neoplasms, Germ Cell And Embryonal Germ Cell Neoplasm Germ Cell Tumour Malignant Tumor Of The Germ Cell Neoplasms Germ Cell Malignant Germ Cell Neoplasm
Germ Cell And Embryonal Cancer	Germ Cell And Embryonal Neoplasm
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14330	TDGF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16445	TDGF1P3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991640	Anti-TDGF1 antibody (huB3F6)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TDGF1	MGD	MGI:98658
Rattus norvegicus	TDGF1	RGD	RGD:1594185