Antimicrobial agent-51

Antimicrobial agent-51 (compound 2f) (72 h) potently inhibits mycelial growth of Fusarium solani, Alternaria solani, Alternaria brassicae, Alternaria sp., Curvularia lunata and Colletotrichum gloeosporioides in vitro, with a mean EC₅₀ of 0.478 μg/mL against these six fungi^[1].
Antimicrobial agent-51 (0.4 mg/mL) disrupts the mycelial morphology and cellular ultrastructure of Alternaria brassicae, causing physical damage and cellular dysfunction; it significantly increases the ROS level in the mycelia of Colletotrichum gloeosporioides to induce oxidative stress; it reduces the mitochondrial membrane potential of Colletotrichum gloeosporioides mycelia, impairs membrane structural integrity, and increases the cell membrane permeability of mycelia^[1].
Antimicrobial agent-51 inhibits succinate dehydrogenase activity in Colletotrichum gloeosporioides with an IC₅₀ of 0.76 μg/mL, thereby disrupting fungal energy metabolism^[1].
Antimicrobial agent-51 (12.5-200 μM, 12 h) exhibits low cytotoxicity against RAW264.7 mouse macrophages, with a cell viability rate of ≥88.7% at the highest concentration of 200 μM, indicating its safety to mammals^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.