AZ-TAK1
AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines.
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- CAS No.: 1413440-36-4
- Formule: C25H28FN7O2
- Masse moléculaire:477.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LoVo | IC50 |
75 nM
Compound: 2
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Growth inhibition of human LoVo cells after 96 hrs by SRB assay
Growth inhibition of human LoVo cells after 96 hrs by SRB assay
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[PMID: 30576901] |
| SK-CO-1 | IC50 |
61 nM
Compound: 2
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Growth inhibition of human SKCO1 cells after 96 hrs by SRB assay
Growth inhibition of human SKCO1 cells after 96 hrs by SRB assay
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[PMID: 30576901] |
| SW-620 | IC50 |
38 nM
Compound: 2
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Growth inhibition of human SW620 cells after 96 hrs by SRB assay
Growth inhibition of human SW620 cells after 96 hrs by SRB assay
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[PMID: 30576901] |
AZ-TAK1 (0.1μM) induces apoptosis in 28%, 24%, and 74% of Mino, SP53, and Jeko cells, respectively[1].
AZ-TAK1 increases mitochondrial depolarization, indicated by a decrease in the red/green fluorescence intensity ratio[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1413440-36-4
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Masse moléculaire 477.53
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Formule C25H28FN7O2
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SMILES
FC1=C(C2=CN=C3C=CC=NN32)N=C(NC4=CC(OCCN5CCC(CC5)O)=CC(CC)=C4)N=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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