Chlorthalidone-d4
Based on 1 Customer Validation
Chlorthalidone-d4 is the deuterium labeled Chlorthalidone. Chlorthalidone is a thiazide-like diuretic used to treat hypertension.
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- Pureté: 97.56%
- CAS No.: 1794941-44-8
- Formule: C14H7D4ClN2O4S
- Masse moléculaire:342.79
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1794941-44-8
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Unlabeled Cas 77-36-1
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Appearance Solid
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Masse moléculaire 342.79
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Formule C14H7D4ClN2O4S
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Color White to off-white
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SMILES
OC1(C2=CC(S(N)(=O)=O)=C(C=C2)Cl)C3=C([2H])C([2H])=C([2H])C([2H])=C3C(N1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 41 mg/mL (119.61 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Barrios V, et al. Which thiazide to choose as add-on therapy for hypertension? Integr Blood Press Control. 2014 Jul 30;7:35-47.;Ettinger B, et al. Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol. 1988 Apr;139(4):679-84. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9172 mL | 14.5862 mL | 29.1724 mL | 72.9309 mL |
| 5 mM | 0.5834 mL | 2.9172 mL | 5.8345 mL | 14.5862 mL | |
| 10 mM | 0.2917 mL | 1.4586 mL | 2.9172 mL | 7.2931 mL | |
| 15 mM | 0.1945 mL | 0.9724 mL | 1.9448 mL | 4.8621 mL | |
| 20 mM | 0.1459 mL | 0.7293 mL | 1.4586 mL | 3.6465 mL | |
| 25 mM | 0.1167 mL | 0.5834 mL | 1.1669 mL | 2.9172 mL | |
| 30 mM | 0.0972 mL | 0.4862 mL | 0.9724 mL | 2.4310 mL | |
| 40 mM | 0.0729 mL | 0.3647 mL | 0.7293 mL | 1.8233 mL | |
| 50 mM | 0.0583 mL | 0.2917 mL | 0.5834 mL | 1.4586 mL | |
| 60 mM | 0.0486 mL | 0.2431 mL | 0.4862 mL | 1.2155 mL | |
| 80 mM | 0.0365 mL | 0.1823 mL | 0.3647 mL | 0.9116 mL | |
| 100 mM | 0.0292 mL | 0.1459 mL | 0.2917 mL | 0.7293 mL |
Chlorthalidone-d4 Related Classifications
HY-15833S Related Classifications
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