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Cat. No.: HY-101521

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CHMFL-BTK-01

CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC₅₀ of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation.

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CAS No.: 2095280-64-9
Formule: C₃₈H₄₁N₅O₅
Masse moléculaire:647.76

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CHMFL-BTK-01 Chemical Structure

CAS No.: 2095280-64-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC₅₀ of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation^[1].

IC₅₀ & Target

IC50: 7 nM (BTK)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	GI₅₀	2.1 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human MV411 cells Growth inhibition of human MV411 cells	[PMID: 28315597]
NB-4	GI₅₀	6.6 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human NB4 cells Growth inhibition of human NB4 cells	[PMID: 28315597]
OCI-AML-3	GI₅₀	3.8 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human OCI-AML3 cells Growth inhibition of human OCI-AML3 cells	[PMID: 28315597]
Pfeiffer	GI₅₀	4.5 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human Pfeiffer cells Growth inhibition of human Pfeiffer cells	[PMID: 28315597]
Ramos	GI₅₀	3.5 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human Ramos cells Growth inhibition of human Ramos cells	[PMID: 28315597]
SKM-1	GI₅₀	7.1 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human SKM1 cells Growth inhibition of human SKM1 cells	[PMID: 28315597]
SU-DHL-2	GI₅₀	3 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human SU-DHL-2 cells Growth inhibition of human SU-DHL-2 cells	[PMID: 28315597]
U2932	GI₅₀	2.4 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human U2932 cells Growth inhibition of human U2932 cells	[PMID: 28315597]
U-937	GI₅₀	4.8 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human U937 cells Growth inhibition of human U937 cells	[PMID: 28315597]

Chemical Information

CAS No. 2095280-64-9
Masse moléculaire 647.76
Formule C₃₈H₄₁N₅O₅
SMILES

O=C(NC1=CC=CC(C(C=C2NC3=CC=C(C(N4CCOCC4)=O)C(NC(C=C)=O)=C3)=CN(C)C2=O)=C1C)C5=CC=C(C(C)(C)C)C=C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Liang Q, et al. Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inh [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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