2095280-64-9
2095280-64-9
Chemical Structure
CHMFL-BTK-01
- CAS No.: 2095280-64-9
- Formula:C38H41N5O5
- Molecular Weight:647.76
IUPAC Name: N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide
InChIKey: UBXBHXGYYBYXOB-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C(C=C2NC3=CC=C(C(N4CCOCC4)=O)C(NC(C=C)=O)=C3)=CN(C)C2=O)=C1C)C5=CC=C(C(C)(C)C)C=C5
Biological Activity: CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC50 of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation[1].
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CHMFL-BTK-01 | CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC50 of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation. | |||||||||||||||||||||
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References
Keywords
