2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. CHMFL-BTK-01

CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC50 of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation.

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CHMFL-BTK-01

CHMFL-BTK-01 Chemical Structure

CAS No. : 2095280-64-9

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CHMFL-BTK-01 Related Antibodies

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Description

CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC50 of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation[1].

IC50 & Target

IC50: 7 nM (BTK)[1].
Cellular Effect
Cell Line Type Value Description References
MV4-11 GI50
2.1 μM
Compound: 9; CHMFL-BTK-01
Growth inhibition of human MV411 cells
Growth inhibition of human MV411 cells
[PMID: 28315597]
NB-4 GI50
6.6 μM
Compound: 9; CHMFL-BTK-01
Growth inhibition of human NB4 cells
Growth inhibition of human NB4 cells
[PMID: 28315597]
OCI-AML-3 GI50
3.8 μM
Compound: 9; CHMFL-BTK-01
Growth inhibition of human OCI-AML3 cells
Growth inhibition of human OCI-AML3 cells
[PMID: 28315597]
Pfeiffer GI50
4.5 μM
Compound: 9; CHMFL-BTK-01
Growth inhibition of human Pfeiffer cells
Growth inhibition of human Pfeiffer cells
[PMID: 28315597]
Ramos GI50
3.5 μM
Compound: 9; CHMFL-BTK-01
Growth inhibition of human Ramos cells
Growth inhibition of human Ramos cells
[PMID: 28315597]
SKM-1 GI50
7.1 μM
Compound: 9; CHMFL-BTK-01
Growth inhibition of human SKM1 cells
Growth inhibition of human SKM1 cells
[PMID: 28315597]
SU-DHL-2 GI50
3 μM
Compound: 9; CHMFL-BTK-01
Growth inhibition of human SU-DHL-2 cells
Growth inhibition of human SU-DHL-2 cells
[PMID: 28315597]
U-937 GI50
4.8 μM
Compound: 9; CHMFL-BTK-01
Growth inhibition of human U937 cells
Growth inhibition of human U937 cells
[PMID: 28315597]
U2932 GI50
2.4 μM
Compound: 9; CHMFL-BTK-01
Growth inhibition of human U2932 cells
Growth inhibition of human U2932 cells
[PMID: 28315597]
Molecular Weight

647.76

Formula

C38H41N5O5
CAS No.
SMILES

O=C(NC1=CC=CC(C(C=C2NC3=CC=C(C(N4CCOCC4)=O)C(NC(C=C)=O)=C3)=CN(C)C2=O)=C1C)C5=CC=C(C(C)(C)C)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CHMFL-BTK-01 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHMFL-BTK-012095280-64-9BtkBruton tyrosine kinaseInhibitorinhibitorinhibit

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Product Name:
CHMFL-BTK-01
Cat. No.:
HY-101521
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