FLT3-IN-4
Based on 1 Customer Validation
FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor for treating acute myelogenous leukemia.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.73%
- CAS No.: 2304799-09-3
- Formule: C23H25N7O2
- Masse moléculaire:431.49
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Kinase Inhibitor Library
HY-L009
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Protein Tyrosine Kinase Compound Library
HY-L016
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Anti-Cancer Compound Library
HY-L025
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Anti-Blood Cancer Compound Library
HY-L079
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Membrane Protein-targeted Compound Library
HY-L149
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Cytokine Inhibitors Library
HY-L161
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
0.92 nM
Compound: 9u
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Antiproliferative activity against mouse BAF3 cells harboring FLT3-ITD mutant measured after 72 hrs by MTT assay
Antiproliferative activity against mouse BAF3 cells harboring FLT3-ITD mutant measured after 72 hrs by MTT assay
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[PMID: 30939008] |
| BaF3 | IC50 |
12.99 nM
Compound: 9u
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Antiproliferative activity against mouse BAF3 cells harboring FLT3-ITD-F691L mutant measured after 72 hrs by MTT assay
Antiproliferative activity against mouse BAF3 cells harboring FLT3-ITD-F691L mutant measured after 72 hrs by MTT assay
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[PMID: 30939008] |
| BaF3 | IC50 |
20.71 nM
Compound: 9u
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Antiproliferative activity against mouse BAF3 cells harboring FLT3-ITD-D835V mutant measured after 72 hrs by MTT assay
Antiproliferative activity against mouse BAF3 cells harboring FLT3-ITD-D835V mutant measured after 72 hrs by MTT assay
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[PMID: 30939008] |
| HL-60 | IC50 |
>1000 nM
Compound: 9u
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Antiproliferative activity against human HL60 cells harboring wild-type FLT3 measured after 72 hrs by MTT assay
Antiproliferative activity against human HL60 cells harboring wild-type FLT3 measured after 72 hrs by MTT assay
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[PMID: 30939008] |
| MOLM-13 | IC50 |
0.022 nM
Compound: 9u
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Antiproliferative activity against human MOLM13 cells harboring FLT3-ITD mutant measured after 72 hrs by MTT assay
Antiproliferative activity against human MOLM13 cells harboring FLT3-ITD mutant measured after 72 hrs by MTT assay
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[PMID: 30939008] |
| MV4-11 | IC50 |
0.089 nM
Compound: 9u
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Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant measured after 72 hrs by MTT assay
Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant measured after 72 hrs by MTT assay
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[PMID: 30939008] |
| RS4-11 | IC50 |
>1000 nM
Compound: 9u
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Antiproliferative activity against human RS4:11 cells harboring wild-type FLT3 measured after 72 hrs by MTT assay
Antiproliferative activity against human RS4:11 cells harboring wild-type FLT3 measured after 72 hrs by MTT assay
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[PMID: 30939008] |
FLT3-IN-4 (Compound 9u) shows potent inhibitory activities against MV4-11 and Molm-13 cells with IC50 values are 0.089±0.001 nM and 0.022±0.003 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2304799-09-3
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Appearance Solid
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Masse moléculaire 431.49
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Formule C23H25N7O2
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Color White to off-white
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SMILES
C=CCN1C2=NC=NC(N)=C2C(C3=CC=C(NC(NC4=NOC(C(C)(C)C)=C4)=O)C=C3)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 25 mg/mL (57.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3176 mL | 11.5878 mL | 23.1755 mL | 57.9388 mL |
| 5 mM | 0.4635 mL | 2.3176 mL | 4.6351 mL | 11.5878 mL | |
| 10 mM | 0.2318 mL | 1.1588 mL | 2.3176 mL | 5.7939 mL | |
| 15 mM | 0.1545 mL | 0.7725 mL | 1.5450 mL | 3.8626 mL | |
| 20 mM | 0.1159 mL | 0.5794 mL | 1.1588 mL | 2.8969 mL | |
| 25 mM | 0.0927 mL | 0.4635 mL | 0.9270 mL | 2.3176 mL | |
| 30 mM | 0.0773 mL | 0.3863 mL | 0.7725 mL | 1.9313 mL | |
| 40 mM | 0.0579 mL | 0.2897 mL | 0.5794 mL | 1.4485 mL | |
| 50 mM | 0.0464 mL | 0.2318 mL | 0.4635 mL | 1.1588 mL |
FLT3-IN-4 Related Classifications
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