EMC8 - ER membrane protein complex subunit 8 Gene

Also Known as NOC4; COX4NB; C16orf2; C16orf4; FAM158B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10328

About EMC8

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:85,778,624-85,799,544 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 7.1), testis (RPKM 6.1) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in cytosol. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

EMC8 Products (2)

mRNA Protein Name
NM_001142288.2 NP_001135760.1 ER membrane protein complex subunit 8 isoform 2
NM_006067.5 NP_006058.1 ER membrane protein complex subunit 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
contributes to membrane insertase activity IMP
IMP: Inferred from mutant phenotype
29809151 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Références Source
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IDA
IDA: Inferred from direct assay
29242231 GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IMP
IMP: Inferred from mutant phenotype
29809151 GOA
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
29242231 GOA
Cellular Component GO Annotation Evidence Références Source
part of EMC complex IDA
IDA: Inferred from direct assay
22119785 GOA
part of EMC complex IPI
IPI: Inferred from physical interaction
32439656 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
22119785 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMC8 Protein Structure

UPF0172

UPF0172: Uncharacterised protein family (UPF0172) (1 - 204)

  • 0
  • 100
  • 200
  • 210 a.a.
Protein Preferred Names Protein Names

ER membrane protein complex subunit 8

  • COX4 neighbor

EMC8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
EMC8 O43402 EMC2 Homo sapiens Q15006
Anti Tag CoIP
35271311
Intra
EMC8 O43402 EMC2 Homo sapiens Q15006
Anti Tag CoIP
32439656
Intra
EMC8 O43402 EMC2 Homo sapiens Q15006
Validated Y2H
32296183
Intra
EMC8 O43402 EMC2 Homo sapiens Q15006
Pull Down
22119785
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EMC8 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P77342 COX4NB Protein, Human (His) O43402-1 (M1-C210) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04342 EMC8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EMC8 VGNC VGNC:72259
Canis familiaris EMC8 VGNC VGNC:40337
Rattus norvegicus EMC8 RGD RGD:1311219
Bos taurus EMC8 VGNC VGNC:28467
Mus musculus EMC8 MGD MGI:1343095
Others EMC8 NCBI