ASB6 - ankyrin repeat and SOCS box containing 6 Gene
Species: Homo sapiens
About ASB6
This gene has 3 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in testis (RPKM 8.1), bone marrow (RPKM 7.8) and 25 other tissues.
Summary
The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four Other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]
ASB6 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001202403.2 | NP_001189332.1 | ankyrin repeat and SOCS box protein 6 isoform 3 |
| NM_017873.4 | NP_060343.1 | ankyrin repeat and SOCS box protein 6 isoform 1 |
| NM_177999.3 | NP_821066.1 | ankyrin repeat and SOCS box protein 6 isoform 2 |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16325183 | GOA |
ASB6 Protein Structure
Ank_2: Ankyrin repeats (3 copies) (43 - 133)
Ank_2: Ankyrin repeats (3 copies) (139 - 205)
SOCS_box: SOCS box (372 - 411)
- 0
- 100
- 200
- 300
- 400
- 421 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ankyrin repeat and SOCS box protein 6 |
|
ASB6 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
ASB6 | Q9NWX5 | FAM9B | Homo sapiens | Q8IZU0 | 25416956 | |
|
Intra
|
ASB6 | Q9NWX5 | CUL5 | Homo sapiens | Q93034 | 21145461 | |
|
Intra
|
ASB6 | Q9NWX5 | CUL5 | Homo sapiens | Q93034 | 21145461 | |
|
Intra
|
ASB6 | Q9NWX5 | CUL5 | Homo sapiens | Q93034 | 33961781 | |
|
Intra
|
ASB6 | Q9NWX5 | CUL5 | Homo sapiens | Q93034 | 16325183 | |
|
Intra
|
ASB6 | Q9NWX5 | CUL5 | Homo sapiens | Q93034 | 28514442 | |
|
Intra
|
ASB6 | Q9NWX5 | ZBTB42 | Homo sapiens | B2RXF5 | 32296183 | |
|
Intra
|
ASB6 | Q9NWX5 | ZBTB42 | Homo sapiens | B2RXF5 | 32296183 | |
|
Intra
|
ASB6 | Q9NWX5 | SH2B2 | Homo sapiens | O14492-2 | 32296183 | |
|
Intra
|
ASB6 | Q9NWX5 | SH2B2 | Homo sapiens | O14492-2 | 32296183 | |
|
Intra
|
ASB6 | Q9NWX5 | RNF41 | Homo sapiens | Q9H4P4 | 28514442 | |
|
Intra
|
ASB6 | Q9NWX5 | RNF41 | Homo sapiens | Q9H4P4 | 32296183 | |
|
Intra
|
ASB6 | Q9NWX5 | RNF41 | Homo sapiens | Q9H4P4 | 25416956 | |
|
Intra
|
ASB6 | Q9NWX5 | RNF41 | Homo sapiens | Q9H4P4 | 33961781 | |
|
Intra
|
ASB6 | Q9NWX5 | RNF41 | Homo sapiens | Q9H4P4 | 25416956 | |
|
Intra
|
ASB6 | Q9NWX5 | RNF41 | Homo sapiens | Q9H4P4 | 32296183 | |
|
Intra
|
ASB6 | Q9NWX5 | L3MBTL3 | Homo sapiens | Q96JM7 | 25416956 | |
|
Intra
|
ASB6 | Q9NWX5 | L3MBTL3 | Homo sapiens | Q96JM7 | 25416956 | |
|
Intra
|
ASB6 | Q9NWX5 | POLR2A | Homo sapiens | P24928 | 32296183 | |
|
Intra
|
ASB6 | Q9NWX5 | POLR2A | Homo sapiens | P24928 | 33961781 | |
|
Intra
|
ASB6 | Q9NWX5 | POLR2A | Homo sapiens | P24928 | 32296183 | |
|
Intra
|
ASB6 | Q9NWX5 | POLR2A | Homo sapiens | P24928 | 28514442 | |
|
Intra
|
ASB6 | Q9NWX5 | RNF7 | Homo sapiens | Q9UBF6 | 16325183 | |
|
Intra
|
ASB6 | Q9NWX5 | ZNF655 | Homo sapiens | Q8N720 | 32296183 | |
|
Intra
|
ASB6 | Q9NWX5 | ZNF655 | Homo sapiens | Q8N720 | 32296183 |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | ASB6 | RGD | RGD:1308445 |
| Canis familiaris | ASB6 | VGNC | VGNC:38166 |
| Felis catus | ASB6 | VGNC | VGNC:59962 |
| Bos taurus | ASB6 | VGNC | VGNC:26199 |
| Mus musculus | ASB6 | MGD | MGI:1919573 |
| Macaca mulatta | ASB6 | VGNC | VGNC:69850 |
| Others | ASB6 | NCBI |