Dlg1 - discs large MAGUK scaffold protein 1 Gene

Also Known as Dlgh1; SAP97

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25252

Summary

Enables several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and Kinesin binding activity. Involved in several processes, including cell adhesion; neurotransmitter receptor localization to postsynaptic specialization membrane; and positive regulation of potassium ion transport. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and paranode region of axon. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dlg1 Products (2)

mRNA Protein Name
NM_001393734.1 NP_001380663.1 disks large homolog 1 isoform 2
NM_012788.2 NP_036920.2 disks large homolog 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
15024025 RGD
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
14597197 RGD
enables kinesin binding IPI
IPI: Inferred from physical interaction
12097473 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
1127911 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12933808 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
11181181 RGD
Biological Process GO Annotation Evidence Références Source
involved in cell adhesion IEP
IEP: Inferred from expression pattern
7891172 RGD
involved in cellular response to brain-derived neurotrophic factor stimulus IDA
IDA: Inferred from direct assay
14597197 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
14597197 RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
12805297 RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
12805297 RGD
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
14597197 RGD
involved in positive regulation of potassium ion transport IMP
IMP: Inferred from mutant phenotype
19213956 RGD
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
17635915 RGD
Cellular Component GO Annotation Evidence Références Source
located in T-tubule IDA
IDA: Inferred from direct assay
11181181 RGD
located in basal plasma membrane IDA
IDA: Inferred from direct assay
7891172 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11726633 RGD
located in cytosol IDA
IDA: Inferred from direct assay
19587293 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17301176 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11029631 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
12805297 RGD
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
8638125 RGD
located in microvillus IDA
IDA: Inferred from direct assay
19587293 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8638125 RGD
located in paranode region of axon IDA
IDA: Inferred from direct assay
19587293 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
17301176 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
11029631 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
7891172 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
8638125 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disks large homolog 1

  • Drosophila discs-large tumor suppressor homologue (synapse associated protein)

  • discs large homolog 1, scribble cell polarity complex component

  • discs, large homolog 1

  • synapse-associated protein 97

Dlg1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
Dlg1 Q62696 DLGAP1 Homo sapiens O14490
FPS
22117215
Cross
Dlg1 Q62696 BTRC Homo sapiens Q9Y297
Pull Down
12902344
Intra
Dlg1 Q62696 Dlg4 Rattus norvegicus P31016
Anti Bait CoIP
21119615
Intra
Dlg1 Q62696 Dlg4 Rattus norvegicus P31016
Anti Bait CoIP
16332687
Intra
Dlg1 Q62696 Map1a Rattus norvegicus P34926
Far-WB
9786987
Cross
Dlg1 Q62696 PTEN Homo sapiens P60484
Pull Down
15951562
Intra
Dlg1 Q62696 Kcnj2 Rattus norvegicus Q64273
Anti Bait CoIP
22509027
Cross
Dlg1 Q62696 E4 Human adenovirus D P89079
Anti Tag CoIP
16511562
Cross
Dlg1 Q62696 E4 Human adenovirus D P89079
Anti Bait CoIP
9192623
Cross
Dlg1 Q62696 Gpsm2 Mus musculus Q8VDU0
FPS
22117215
Cross
Dlg1 Q62696 Gpsm2 Mus musculus Q8VDU0
X-Ray Diffraction
22117215
Intra
Dlg1 Q62696 Dgki Rattus norvegicus F1MAB7
Anti Bait CoIP
21119615
Intra
Dlg1 Q62696 Dgki Rattus norvegicus F1MAB7
Pull Down
21119615
Intra
Dlg1 Q62696 Lrfn2 Rattus norvegicus Q460M5
Anti Bait CoIP
16495444
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS03796 DLG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlg1 NCBI NCBI:1739