Kcnj2 - potassium inwardly-rectifying channel, subfamily J, member 2 Gene

Also Known as Kir2.1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29712

Summary

Predicted to enable identical protein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and voltage-gated Potassium Channel activity. Involved in cellular response to mechanical stimulus; positive regulation of potassium ion transmembrane transport; and regulation of cardiac muscle cell contraction. Located in several cellular components, including T-tubule; endoplasmic reticulum; and intercalated disc. Used to study myocardial infarction. Human ortholog(s) of this gene implicated in Andersen-Tawil syndrome; familial atrial fibrillation; familial periodic paralysis; and short QT syndrome. Orthologous to human KCNJ2 (potassium inwardly rectifying channel subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj2 Products (1)

mRNA Protein Name
NM_017296.2 NP_058992.1 inward rectifier potassium channel 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22509027 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
17293496 RGD
involved in positive regulation of potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
22426100 RGD
involved in regulation of cardiac muscle cell contraction IMP
IMP: Inferred from mutant phenotype
22426100 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
23640888 RGD
located in dendrite IDA
IDA: Inferred from direct assay
12591157 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
18076085 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18076085 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
23640888 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12591157 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
18076085 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inward rectifier potassium channel 2

  • IRK-1

  • RBL-IRK1

  • inward rectifier K(+) channel Kir2.1

  • potassium channel, inwardly rectifying subfamily J member 2

  • potassium voltage-gated channel subfamily J member 2

Kcnj2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Kcnj2 Q64273 Dlg1 Rattus norvegicus Q62696
Anti Bait CoIP
22509027
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07145 KCNJ2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20045 Kcnj2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26548 Kcnj2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnj2 NCBI NCBI:3759