Prkaca - protein kinase cAMP-activated catalytic subunit alpha Gene

Also Known as PKCA1; Cs-PKA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25636

About Prkaca

Primary_assembly 19: 24,155,090-24,178,430 reverse strand.mRatBN7.2:CM026992.1

This gene has 5 transcripts (splice variants), 289 orthologues, 4 paralogues and is associated with 13 phenotypes. Biased expression in Heart (RPKM 789.1), Adrenal (RPKM 386.4) and 9 other tissues.

Summary

Enables cAMP-dependent protein kinase activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including circadian sleep/wake cycle, REM sleep; regulation of glutamatergic synaptic transmission; and spontaneous exocytosis of neurotransmitter. Located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and presynapse. Part of cAMP-dependent protein kinase complex. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkaca Products (1)

mRNA Protein Name
NM_001100922.2 NP_001094392.1 cAMP-dependent protein kinase catalytic subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables cAMP-dependent protein kinase activity IDA
IDA: Inferred from direct assay
11907174 RGD
enables cAMP-dependent protein kinase activity IMP
IMP: Inferred from mutant phenotype
17190793 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18381233 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
11035810 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
12672265 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
23419316 RGD
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of meiotic cell cycle IDA
IDA: Inferred from direct assay
16816331 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
15546918 RGD
involved in peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
17190793 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
23349233 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11907174 RGD
involved in regulation of cellular respiration IDA
IDA: Inferred from direct assay
12562968 RGD
involved in regulation of synaptic transmission, glutamatergic IDA
IDA: Inferred from direct assay
12562968 RGD
involved in spontaneous exocytosis of neurotransmitter IMP
IMP: Inferred from mutant phenotype
17190793 RGD
Cellular Component GO Annotation Evidence Références Source
part of cAMP-dependent protein kinase complex IDA
IDA: Inferred from direct assay
11907174 RGD
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
11716788 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18550536 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
11716788 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
11716788 RGD
located in presynapse IMP
IMP: Inferred from mutant phenotype
17190793 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12672265 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkaca Protein Structure

STKc_PKA

STKc_PKA: cd14209 (41 - 330)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

cAMP-dependent protein kinase catalytic subunit alpha

  • PKA C-alpha

  • cAMP-dependent protein kinase catalytic subunit C alpha

  • protein kinase A

  • protein kinase, cAMP-dependent, alpha catalytic subunit

  • protein kinase, cAMP-dependent, catalytic, alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-153967 BLU0588 Inhibitor 97.63% Unkown
HY-150076 BLU2864 Inhibitor 99.50% Unkown
HY-150072 DS89002333 Inhibitor 99.85% Unkown
HY-RS11116 PRKCA Human Pre-designed siRNA Set A / Unkown
HY-150072B (R)-DS89002333 Control 98.74% Unkown
HY-RS11104 PRKACA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-150072A (2S,4R)-DS89002333 Control / Unkown
HY-150073 DS01080522 Inhibitor / Unkown
HY-RS11105 Prkaca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11106 Prkaca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkaca NCBI NCBI:5566