CYP11B1 - Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 Gene

Also Known as Cp11ba; CYPXIB1; P450C11; RATCP11BA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 500892

Summary

Enables steroid 11-beta-monooxygenase activity and steroid binding activity. Involved in several processes, including cellular response to interferon-gamma; primary alcohol biosynthetic process; and response to dexamethasone. Located in mitochondrion. Is integral component of endoplasmic reticulum membrane. Used to study hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (Cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (Cytochrome P450 family 11 subfamily B member 2). [provided by Alliance of Genome Resources, Apr 2022]

CYP11B1 Products (1)

mRNA Protein Name
NM_012537.3 NP_036669.3 cytochrome P450 11B1, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables steroid 11-beta-monooxygenase activity IDA
IDA: Inferred from direct assay
16405651 RGD
enables steroid binding IDA
IDA: Inferred from direct assay
16405651 RGD
Biological Process GO Annotation Evidence Références Source
involved in adenosine metabolic process IEP
IEP: Inferred from expression pattern
20937274 RGD
involved in aldosterone biosynthetic process IMP
IMP: Inferred from mutant phenotype
19342457 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
12121434 RGD
involved in cortisol biosynthetic process IMP
IMP: Inferred from mutant phenotype
19342457 RGD
involved in dibenzo-p-dioxin metabolic process IEP
IEP: Inferred from expression pattern
16254025 RGD
involved in glucocorticoid biosynthetic process IDA
IDA: Inferred from direct assay
19665544 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
18252953 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19733641 RGD
involved in steroid biosynthetic process IDA
IDA: Inferred from direct assay
16405651 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 11B1, mitochondrial

  • Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase)

  • P450(11 beta)-DS

  • aldosterone synthase

  • cytochrome P450 11B1, mitochondrial-like

  • cytochrome P450(11 beta)-DS

  • cytochrome P450, subfamily 11B, polypeptide 1

  • cytochrome P450C11

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-16276 Osilodrostat Inhibitor 99.82% Yes
HY-16276A Osilodrostat phosphate Inhibitor 98.83% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Phase
HY-B0105B Levoketoconazole Inhibitor 99.82% Phase 3
HY-113986 Dexfadrostat Inhibitor 98.75% Phase 2

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-135794 11-Ketodihydrotestosterone Agonist 99.87% Unkown
HY-163689 Vicadrostat Inhibitor 98.67% Unkown
HY-101217 BI 689648 Inhibitor 99.20% Unkown
HY-135281 CYP11B2-IN-1 Inhibitor 99.83% Unkown
HY-113986C Dexfadrostat hydrochloride Inhibitor / Unkown
HY-122744 CYP11B1-IN-1 Inhibitor / Unkown
HY-151140 CYP11B1-IN-2 Inhibitor / Unkown
HY-176480 CYP11B2-IN-3 Inhibitor / Unkown
HY-RS03435 CYP11B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116666 Etomidate acid / Unkown
HY-163751 STING-IN-9 Inhibitor / Unkown
HY-RS17315 Cyp11b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23770 Cyp11b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CYP11B1 NCBI NCBI:1584