CYP11B1-IN-1

CYP11B1-IN-1 (Compound 25) potently inhibits hCYP11B1 (IC₅₀ = 2 nM), and exhibits 14-fold higher selectivity for hCYP11B1 over hCYP11B2 in V79MZ hamster fibroblasts expressing recombinant enzymes^[1].
CYP11B1-IN-1 inhibits rat CYP11B1, with an IC₅₀ of 1.8 μM in V79MZ hamster fibroblasts expressing this recombinant enzyme^[1].
CYP11B1-IN-1 (1 μM; 0-60 min) exhibits superior metabolic stability in rat liver S9 fractions, with a half-life of 23 min, which is better than that of Ref 7 and metyrapone^[1].
CYP11B1-IN-1 (6.25-100 μM; 66 h) shows no cytotoxicity in HEK293 cells, with an IC₂₀ value of up to 42 μM^[1].
CYP11B1-IN-1 (up to 100 μM) shows no mutagenic potential in *Salmonella typhimurium* strains TA98 and TAMix, with or without metabolic activation by rat liver S9 fraction^[1].
CYP11B1-IN-1 (3.16 μM; 48 h) does not activate the aryl hydrocarbon receptor in HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.