Porcn - porcupine O-acyltransferase Gene

Also Known as Ppn; Mg61; porc; Mporc; mMg61; DXHXS7465e; 2410004O13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53627

About Porcn

Chromosome X: 8,060,087-8,072,764 reverse strand.GRCm39:CM001013.3

This gene has 7 transcripts (splice variants), 268 orthologues, 5 paralogues and is associated with 33 phenotypes. Broad expression in cerebellum adult (RPKM 42.), ovary adult (RPKM 21.2) and 21 other tissues.

Summary

Enables Wnt-protein binding activity and palmitoleoyltransferase activity. Involved in Wnt signaling pathway; protein palmitoleylation; and regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within canonical Wnt signaling pathway and glycoprotein metabolic process. Located in endoplasmic reticulum and glutamatergic synapse. Is integral component of endoplasmic reticulum membrane. Part of AMPA glutamate receptor complex. Is expressed in several structures, including anterior visceral endoderm; eye; genitourinary system; nervous system; and primitive streak. Used to study focal dermal hypoplasia. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to human PORCN (Porcupine O-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Porcn Products (5)

mRNA Protein Name
NM_016913.4 NP_058609.1 protein-serine O-palmitoleoyltransferase porcupine isoform A
NM_145907.4 NP_665914.1 protein-serine O-palmitoleoyltransferase porcupine isoform C
NM_001308474.1 NP_001295403.1 protein-serine O-palmitoleoyltransferase porcupine isoform E
NM_145908.4 NP_665915.1 protein-serine O-palmitoleoyltransferase porcupine isoform B
NM_023638.4 NP_076127.1 protein-serine O-palmitoleoyltransferase porcupine isoform D

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
24798332 MGI
enables palmitoleoyltransferase activity IDA
IDA: Inferred from direct assay
24798332 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10866835 MGI
Biological Process GO Annotation Evidence Références Source
involved in Wnt signaling pathway IDA
IDA: Inferred from direct assay
24798332 MGI
involved in Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
17141155 MGI
acts upstream of or within glycoprotein metabolic process IDA
IDA: Inferred from direct assay
10866835 MGI
involved in protein lipidation IDA
IDA: Inferred from direct assay
17141155 MGI
involved in protein palmitoleylation IDA
IDA: Inferred from direct assay
24798332 MGI
involved in protein palmitoleylation IMP
IMP: Inferred from mutant phenotype
17141155 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: Inferred from direct assay
26776514 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
IEP: Inferred from expression pattern
26776514 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: Inferred from mutant phenotype
26776514 MGI
Cellular Component GO Annotation Evidence Références Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
22632720 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
24798332 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
10866835 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
26776514 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
26776514 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
26776514 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Porcn Protein Structure

MBOAT

MBOAT: cl00738 (30 - 342)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
Protein Preferred Names Protein Names

protein-serine O-palmitoleoyltransferase porcupine

  • porcupine homolog

  • probable protein-cysteine N-palmitoyltransferase porcupine

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Phase
HY-17545 LGK974 Inhibitor 99.93% Phase 2
HY-18988 ETC-159 Inhibitor 99.13% Phase 1

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-13912 IWP-2 Inhibitor 99.93% Unkown
HY-15659 Wnt-C59 Inhibitor 99.92% Unkown
HY-15825 IWP L6 Inhibitor 98.71% Unkown
HY-13912G IWP-2 (GMP) Inhibitor / Unkown
HY-100536 IWP-3 Inhibitor 98.10% Unkown
HY-100853 IWP-O1 Inhibitor 99.81% Unkown
HY-111472 Porcn-IN-1 Inhibitor 99.57% Unkown
HY-15659G Wnt-C59 (GMP) Inhibitor / Unkown
HY-107570 IWP-12 Inhibitor 99.53% Unkown
HY-12879G IWP-4 (GMP) Inhibitor / Unkown
HY-156551 Porcn-IN-2 Inhibitor / Unkown
HY-15825G IWP L6 (GMP) Inhibitor / Unkown
HY-176488 Y-99 Inhibitor / Unkown
HY-P11606 WNT3Ap Substrate / Unkown
HY-RS10881 PORCN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10882 Porcn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10883 Porcn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-164547 WHN-88 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Porcn NCBI NCBI:64840