Crk - CRK proto-oncogene, adaptor protein Gene

Also Known as Crko; CrkII

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54245

Summary

Enables several functions, including insulin-like growth factor receptor binding activity; protein tyrosine kinase binding activity; and scaffold protein binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to nitric oxide; and response to peptide hormone. Located in membrane raft. Biomarker of degenerative disc disease. Orthologous to human CRK (CRK proto-oncogene, adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]

Crk Products (1)

mRNA Protein Name
NM_019302.1 NP_062175.1 adapter molecule crk

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables cytoskeletal protein binding IPI
IPI: Inferred from physical interaction
17615370 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
9348226 RGD
enables insulin-like growth factor receptor binding IPI
IPI: Inferred from physical interaction
12837295 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8940134 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
12011056 RGD
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
16187300 RGD
enables protein-macromolecule adaptor activity IMP
IMP: Inferred from mutant phenotype
8901553 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
20623582 RGD
Biological Process GO Annotation Evidence Références Source
involved in cellular response to endothelin IPI
IPI: Inferred from physical interaction
12719447 RGD
involved in cellular response to insulin-like growth factor stimulus IPI
IPI: Inferred from physical interaction
12837295 RGD
involved in cellular response to nerve growth factor stimulus IDA
IDA: Inferred from direct assay
15128873 RGD
involved in cellular response to nitric oxide IPI
IPI: Inferred from physical interaction
12714323 RGD
involved in cellular response to transforming growth factor beta stimulus IPI
IPI: Inferred from physical interaction
12837295 RGD
involved in negative regulation of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
18835194 RGD
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
12198159 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
12714323 RGD
involved in protein localization to membrane IMP
IMP: Inferred from mutant phenotype
12198159 RGD
involved in regulation of Rac protein signal transduction IMP
IMP: Inferred from mutant phenotype
12198159 RGD
involved in response to cholecystokinin IDA
IDA: Inferred from direct assay
14622258 RGD
involved in response to hepatocyte growth factor IPI
IPI: Inferred from physical interaction
16187300 RGD
involved in response to hydrogen peroxide IPI
IPI: Inferred from physical interaction
16187300 RGD
involved in response to peptide IPI
IPI: Inferred from physical interaction
14622258 RGD
involved in response to yeast IEP
IEP: Inferred from expression pattern
19958054 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adapter molecule crk

  • avian sarcoma virus CT10 (v-crk) oncogene homolog

  • p38

  • proto-oncogene C-crk

  • v-crk avian sarcoma virus CT10 oncogene homolog

  • v-crk sarcoma virus CT10 oncogene homolog

Crk Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
Crk Q63768 PTPN1 Homo sapiens P18031
Pull Down
12023880
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-112622 GSK3186899 Inhibitor 98.96% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS16222 Crk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112346 RGB-286147 98.60% Unkown
HY-143322 CRK12-IN-2 Inhibitor / Unkown
HY-145812 CRK12-IN-1 Inhibitor / Unkown
HY-RS03184 CRK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23979 Crk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crk NCBI NCBI:1398