SLFN12 - schlafen family member 12 Gene

Also Known as SLFN3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55106

About SLFN12

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,410,922-35,433,174 (from NCBI)

This gene has 8 transcripts (splice variants), 101 orthologues and 6 paralogues. Ubiquitous expression in spleen (RPKM 3.5), urinary bladder (RPKM 3.0) and 24 other tissues.

Summary

Predicted to act upstream of or within negative regulation of cell population proliferation. [provided by Alliance of Genome Resources, Apr 2022]

SLFN12 Products (2)

mRNA Protein Name
NM_001289009.2 NP_001275938.1 ribonuclease SLFN12
NM_018042.5 NP_060512.3 ribonuclease SLFN12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables RNA nuclease activity IDA
IDA: Inferred from direct assay
34272366 GOA
enables RNA nuclease activity IMP
IMP: Inferred from mutant phenotype
35104454 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31420216 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
31420216 GOA
Biological Process GO Annotation Evidence Références Source
involved in apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
31420216 GOA
involved in rRNA catabolic process IDA
IDA: Inferred from direct assay
34272366 GOA
involved in rRNA catabolic process IMP
IMP: Inferred from mutant phenotype
35104454 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytosol IDA
IDA: Inferred from direct assay
35104454 GOA
located in nucleus IDA
IDA: Inferred from direct assay
35104454 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLFN12 Protein Structure

AlbA_2

AlbA_2: Putative DNA-binding domain (200 - 326)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 578 a.a.
Protein Preferred Names Protein Names

ribonuclease SLFN12

schlafen family member 12

SLFN12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SLFN12 Q8IYM2 YARS1 Homo sapiens P54577
Y2H Array
32814053
Intra
SLFN12 Q8IYM2 YARS1 Homo sapiens P54577
Validated Y2H
32814053
Intra
SLFN12 Q8IYM2 YARS1 Homo sapiens P54577
Y2H Pooling
32814053
Intra
SLFN12 Q8IYM2 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
SLFN12 Q8IYM2 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
SLFN12 Q8IYM2 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
SLFN12 Q8IYM2 LPL Homo sapiens P06858
Y2H Array
32814053
Intra
SLFN12 Q8IYM2 LPL Homo sapiens P06858
Y2H Pooling
32814053
Intra
SLFN12 Q8IYM2 LPL Homo sapiens P06858
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

SLFN12 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P86284 SLFN12 Antibody (YA5976) WB, FC Human

Related Diseases

Diseases Alias
Bleeding Disorder, Platelet-Type, 20

  • Platelet-Type Bleeding Disorder 20

  • BDPLT20

  • Autosomal Dominant Thrombocytopenia With Platelet Secretion Defect
Monkeypox

  • Monkeypox Virus Infections
Progesterone-Receptor Positive Breast Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-145924 BAY 2666605 Inhibitor 99.74% Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-W028690 DNMDP Inhibitor 99.46% Unkown
HY-162730 OPB-171775 Inhibitor 99.80% Unkown
HY-122751 (R)-DNMDP Inhibitor 99.59% Unkown
HY-N10149 Nauclefine 99.65% Unkown
HY-153802 Antitumor agent-100 Inducer / Unkown
HY-153802A Antitumor agent-100 hydrochloride Inducer / Unkown
HY-RS13364 SLFN12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13365 SLFN12L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162730R OPB-171775 (Standard) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLFN12 RGD RGD:620455
Others SLFN12 NCBI