2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. BAY 2666605

BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer (WO2019025562A1; example 135).

For research use only. We do not sell to patients.

BAY 2666605 Chemical Structure

BAY 2666605 Chemical Structure

CAS No. : 2275774-60-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 330 In-stock
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Solid
5 mg USD 300 In-stock
10 mg USD 490 In-stock
25 mg USD 1050 In-stock
50 mg USD 1680 In-stock
100 mg USD 2700 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

BAY 2666605 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE BAY 2666605

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer (WO2019025562A1; example 135)[1].

IC50 & Target[1]

PDE3A

87 nM (IC50)

PDE3B

50 nM (IC50)

In Vitro

BAY 2666605 (example 135) has anticancer effects, potently inhibit brain cancer(especially glioma, more specifically glioblastoma, astrocytoma), breast cancer (especially ductal carcinoma and adenocarcinoma), cervical cancer, AML(especially erythroleucemia), lung cancer(especially NSCLC adenocarcinoma and SCLC), skin cancer(especially melanoma), oesophagus cancer (especially squamous cell carcinoma), ovarian cancer, (especially teratocarcinoma, adenocarcinoma), pancreas cancer and prostatic cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY 2666605 Related Antibodies
In Vivo

BAY 2666605 (5 mg/kg; p.o; twice daily) teatment shows anti-tumor efficacy in murine xenotransplantation models of human cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

352.28

Formula

C17H12F4N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(C1=C(C2=CC=C(C=C2)F)C=CC(C([C@@H](O3)C)=NNC3=O)=C1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (709.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8387 mL 14.1933 mL 28.3865 mL
5 mM 0.5677 mL 2.8387 mL 5.6773 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.64%

COA (249 KB) HNMR (258 KB) LCMS (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8387 mL 14.1933 mL 28.3865 mL 70.9663 mL
5 mM 0.5677 mL 2.8387 mL 5.6773 mL 14.1933 mL
10 mM 0.2839 mL 1.4193 mL 2.8387 mL 7.0966 mL
15 mM 0.1892 mL 0.9462 mL 1.8924 mL 4.7311 mL
20 mM 0.1419 mL 0.7097 mL 1.4193 mL 3.5483 mL
25 mM 0.1135 mL 0.5677 mL 1.1355 mL 2.8387 mL
30 mM 0.0946 mL 0.4731 mL 0.9462 mL 2.3655 mL
40 mM 0.0710 mL 0.3548 mL 0.7097 mL 1.7742 mL
50 mM 0.0568 mL 0.2839 mL 0.5677 mL 1.4193 mL
60 mM 0.0473 mL 0.2366 mL 0.4731 mL 1.1828 mL
80 mM 0.0355 mL 0.1774 mL 0.3548 mL 0.8871 mL
100 mM 0.0284 mL 0.1419 mL 0.2839 mL 0.7097 mL
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BAY 2666605 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY 26666052275774-60-0BAY2666605BAY-2666605Phosphodiesterase (PDE)PDE3A-SLFN12 Complexanticancer effectorally activeInhibitorinhibitorinhibit

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