BAY 2666605
Based on 3 publication(s) in Google Scholar
BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer (WO2019025562A1; example 135).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.74%
- CAS. Nr.: 2275774-60-0
- Formel: C17H12F4N2O2
- Molecular Weight:352.28
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BAY 2666605
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
PDE3A 87 nM (IC50) |
PDE3B 50 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
1.3 nM
Compound: 39, BAY 2666605
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 37077378] |
In Vitro
BAY 2666605 (example 135) has anticancer effects, potently inhibit? brain cancer(especially glioma, more specifically glioblastoma, astrocytoma), breast cancer (especially ductal carcinoma and adenocarcinoma), cervical cancer, AML(especially erythroleucemia), lung cancer(especially NSCLC adenocarcinoma and SCLC), skin cancer(especially melanoma), oesophagus cancer (especially squamous cell carcinoma), ovarian cancer, (especially teratocarcinoma, adenocarcinoma), pancreas cancer and prostatic cancer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 2275774-60-0
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Appearance Solid
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Molecular Weight 352.28
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Formel C17H12F4N2O2
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Color White to off-white
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SMILES
FC(F)(C1=C(C2=CC=C(C=C2)F)C=CC(C([C@@H](O3)C)=NNC3=O)=C1)F
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 250 mg/mL (709.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8387 mL | 14.1933 mL | 28.3865 mL | 70.9663 mL |
| 5 mM | 0.5677 mL | 2.8387 mL | 5.6773 mL | 14.1933 mL | |
| 10 mM | 0.2839 mL | 1.4193 mL | 2.8387 mL | 7.0966 mL | |
| 15 mM | 0.1892 mL | 0.9462 mL | 1.8924 mL | 4.7311 mL | |
| 20 mM | 0.1419 mL | 0.7097 mL | 1.4193 mL | 3.5483 mL | |
| 25 mM | 0.1135 mL | 0.5677 mL | 1.1355 mL | 2.8387 mL | |
| 30 mM | 0.0946 mL | 0.4731 mL | 0.9462 mL | 2.3655 mL | |
| 40 mM | 0.0710 mL | 0.3548 mL | 0.7097 mL | 1.7742 mL | |
| 50 mM | 0.0568 mL | 0.2839 mL | 0.5677 mL | 1.4193 mL | |
| 60 mM | 0.0473 mL | 0.2366 mL | 0.4731 mL | 1.1828 mL | |
| 80 mM | 0.0355 mL | 0.1774 mL | 0.3548 mL | 0.8871 mL | |
| 100 mM | 0.0284 mL | 0.1419 mL | 0.2839 mL | 0.7097 mL |
BAY 2666605 Related Classifications
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