PLA2G7 - phospholipase A2 group VII Gene

Also Known as PAFAD; PAFAH; LP-PLA2; LDL-PLA2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7941

About PLA2G7

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:46,704,201-46,735,721 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues, 1 paralogue and is associated with 3 phenotypes. Broad expression in appendix (RPKM 6.4), lymph node (RPKM 5.5) and 18 other tissues.

Summary

The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]

PLA2G7 Products (2)

mRNA Protein Name
NM_001168357.2 NP_001161829.1 platelet-activating factor acetylhydrolase precursor
NM_005084.4 NP_005075.3 platelet-activating factor acetylhydrolase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA
IDA: Inferred from direct assay
8624782 GOA
enables calcium-independent phospholipase A2 activity IDA
IDA: Inferred from direct assay
2040620 GOA
enables phospholipid binding IDA
IDA: Inferred from direct assay
8624782 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Références Source
involved in lipid oxidation IDA
IDA: Inferred from direct assay
8624782 GOA
involved in low-density lipoprotein particle remodeling IDA
IDA: Inferred from direct assay
8624782 GOA
involved in phosphatidylcholine catabolic process IDA
IDA: Inferred from direct assay
2040620 GOA
involved in plasma lipoprotein particle oxidation IDA
IDA: Inferred from direct assay
8624782 GOA
involved in platelet activating factor catabolic process IDA
IDA: Inferred from direct assay
16371369 GOA
involved in platelet activating factor metabolic process IDA
IDA: Inferred from direct assay
8624782 GOA
involved in positive regulation of monocyte chemotaxis IDA
IDA: Inferred from direct assay
8624782 GOA
Cellular Component GO Annotation Evidence Références Source
part of high-density lipoprotein particle IDA
IDA: Inferred from direct assay
11590221 GOA
part of low-density lipoprotein particle IDA
IDA: Inferred from direct assay
8624782 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G7 Protein Structure

PAF-AH_p_II

PAF-AH_p_II: Platelet-activating factor acetylhydrolase, isoform II (49 - 416)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 441 a.a.
Protein Preferred Names Protein Names

platelet-activating factor acetylhydrolase

  • 1-alkyl-2-acetylglycerophosphocholine esterase

PLA2G7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
PLA2G7 Q13093 PTPRN Homo sapiens Q16849
Anti Tag CoIP
28514442
Intra
PLA2G7 Q13093 PTPRN Homo sapiens Q16849
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PLA2G7 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P70993 PLA2G7 Protein, Human (HEK293, His) AAH38452.1 (F22-N441) ≥ 90%, as determined by reducing SDS-PAGE.

PLA2G7 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P84527 PLA2G7 Antibody (YA4224) IHC-P, ICC/IF, ELISA Human
HY-P84527A PLA2G7 Antibody (YA4224)(PBS only) IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Platelet-Activating Factor Acetylhydrolase Deficiency

  • PAFAD

  • Deficiency, Platelet-Activating Factor Acetylhydrolase
Ige Responsiveness, Atopic

  • ATOPY

  • Atopy, Susceptibility To

  • Ige, Elevated Level Of

  • IGER

  • Immunoglobulin E, Basic Level Of, In Serum

  • Ige, Level Of

  • Igel

  • Ige Response Underlying Allergic Asthma And Rhinitis

  • Atopic Hypersensitivity

  • Immediate Hypersensitivity
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Perinatal Necrotizing Enterocolitis

  • Necrotizing Enterocolitis

  • Enterocolitis Necrotizing

  • Enterocolitis, Necrotizing

  • Necrotizing Enterocolitis In Fetus Or Newborn

  • Perinatal Necrotising Enterocolitis

  • Pseudomembranous Enterocolitis In Newborn

  • Nec
Lissencephaly 1

  • LIS1

  • Classic Lissencephaly

  • Ils

  • Subcortical Laminar Heterotopia

  • Lissencephaly Due To Lis1 Mutation

  • Lissencephaly Sequence, Isolated

  • Lissencephaly, Classic

  • Pafah1b1-Related Lissencephaly

  • Classical Lissencephaly

  • Lissencephaly Type 1

  • Lissencephaly-1

  • Subcortical Band Heterotopia

  • Double Cortex

  • Lissencephaly Classic

  • Lissencephaly Sequence Isolated

  • Isolated Lissencephaly Sequence

  • Type 1 Lissencephaly

  • Lissencephaly Syndrome Type 1

  • SBH

  • Sclh

  • Lissencephaly, Type 1

  • Type I Lissencephaly
Adult Respiratory Distress Syndrome

  • Acute Respiratory Distress Syndrome

  • Ards

  • Non-Cardiogenic Pulmonary Edema

  • Acute Lung Injury

  • Respiratory Distress Syndrome, Adult

  • Shock Lung

  • Acute Respiratory Distress

  • Respiratory Distress Syndrome

  • Adult Rds

  • Ali

  • Increased-Permeability Pulmonary Edema

  • Stiff Lung

  • Respiratory Distress Syndrome Adult
Intracranial Thrombosis

  • Cerebral Thrombosis

  • Thrombosis Of Cerebral Veins

  • Cerebral Arterial Thrombosis
Atherosclerosis Susceptibility

  • Atherosclerosis

  • Atherosclerosis, Susceptibility To

  • ATHS

  • Atherogenic Lipoprotein Phenotype

  • Alp

  • Arteriosclerosis
Familial Hypercholesterolemia

  • Hyperlipoproteinemia Type Iia

  • Familial Hyperbetalipoproteinaemia

  • Familial Hypercholesteremia

  • Fredrickson Type Iia Hyperlipoproteinemia

  • Fredrickson Type Iia Lipidaemia

  • Hyperbetalipoproteinemia

  • Type Ii Hyperlipidemia

  • Familial Hypercholesterolæmia

  • Familial Hypercholesterolaemia

  • Fh

  • Hypercholesterolemia Familial

  • Hyperlipoproteinemia Type Ii

  • Hypercholesterolemia, Familial
Lissencephaly

  • Pachygyria

  • Broad Gyri Of Cerebrum

  • Large Gyri Of Cerebrum

  • Macrogyria
Vascular Disease

  • Vascular Diseases

  • Aneurysm

  • Spinal Cord Ischemia

  • Vascular Anomaly

  • Spinal Cord Vascular Diseases

  • Vascular Tissue Disease
Chronic Kidney Disease

  • Chronic Renal Disease

  • Chronic Kidney Failure

  • Ckd

  • Chronic Renal Failure

  • Kidney Failure, Chronic

  • Chronic Renal Failure Syndrome

  • Crf

  • Renal Failure - Chronic

  • Renal Failure Chronic

  • Chronic Kidney Diseases

  • Chronic Kidney Disease Stage 5

  • Ckd - [Chronic Kidney Disease]

  • Crf - [Chronic Renal Failure]

  • Chronic Kidney Impairment

  • Chronic Renal Impairment

  • Chronic Kidney Shutdown

  • Chronic Hypoxic Kidney Failure

  • Chronic Kidney Collapse

  • Chronic Renal Insufficiency

  • Chronic Kidney Toxaemia

  • Chronic Kidney Hypofunction

  • Chronic Renal Suppression

  • Chronic Renal Failure, Stage 5

  • Ckd - [Chronic Kidney Disease] Stage 5

  • End Stage Kidney Failure

  • End Stage Renal Failure

  • End Stage Kidney Disease

  • End Stage Renal Disease

  • End Stage Chronic Renal Failure

  • Esrf - [End Stage Renal Failure]

  • Esrd - [End Stage Renal Diseases]

  • Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Generalized Atherosclerosis

  • Generalised Atherosclerosis
Lipid Metabolism Disorder

  • Dyslipidemia

  • Disorder Of Fatty Acid Metabolism

  • Lipid Metabolism Disorders

  • Fatty Acid Metabolism Disorder

  • Disorder Of Lipid Metabolism

  • Abnormality Of Lipid Metabolism

  • Lipid Metabolism, Inborn Errors

  • Dyslipidemias

  • Disorders Of Lipid Metabolism

  • Congenital Disorders Of Lipid Metabolism

  • Inherited Disorders Of Lipid Metabolism
Juvenile Rheumatoid Arthritis

  • Juvenile Idiopathic Arthritis

  • Juvenile Chronic Polyarthritis

  • Monarticular Juvenile Rheumatoid Arthritis

  • Pauciarticular Juvenile Arthritis

  • Still'S Disease

  • Systemic Juvenile Rheumatoid Arthritis

  • Juvenile Chronic Arthritis

  • Acute Juvenile Rheumatoid Arthritis

  • Pauciarticular Onset Juvenile Chronic Arthritis

  • Arthritis, Juvenile Rheumatoid

  • Jia

  • Jra

  • Juvenile Ra

  • Arthritis Juvenile Rheumatoid

  • Stills Disease

  • Juvenile Arthritis

  • Acute Polyarticular Juvenile Rheumatoid Arthritis

  • Pauciarticular Juvenile Rheumatoid Arthritis

  • Rheumatoid Arthritis, Systemic Juvenile
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Lipoprotein Quantitative Trait Locus

  • Coronary Artery Disease

  • Coronary Artery Anomaly

  • Coronary Artery Disease, Susceptibility To

  • Myocardial Ischemia

  • Congenital Anomaly Of Coronary Artery

  • Coronary Arteriosclerosis

  • Coronary Disease

  • Coronary Heart Disease

  • Coronary Artery Disorder

  • LPAQTL

  • Lpa Deficiency, Congenital

  • Coronary Artery Abnormality

  • Coronary Artery Anomaly, Congenital

  • Chd

  • Coronary Syndrome

  • Congenital Malformations Of Coronary Vessels

  • Malformation Of Coronary Vessels

  • Congenital Coronary Artery Anomaly

  • Congenital Coronary Artery Deformity

  • Congenital Coronary Artery Disorder

  • Abnormal Coronary Artery

  • Congenital Coronary Artery Malposition

  • Congenital Coronary Disease

  • Congenital Anomaly Of Coronary Arteries
Stroke, Ischemic

  • Cerebral Infarction

  • Stroke

  • Ischemic Stroke

  • Cerebrovascular Accident

  • Cerebral Infarction, Susceptibility To

  • Stroke, Ischemic, Susceptibility To

  • Cerebral Infarct

  • Ischemic Stroke, Susceptibility To

  • Stroke, Susceptibility To

  • Cva - Cerebral Infarction

  • ISCHSTR

  • Ischemic Cerebrovascular Accident
Cardiovascular System Disease

  • Abnormality Of The Cardiovascular System

  • Cardiovascular Disease

  • Disease Of Subdivision Of Hemolymphoid System

  • Disorder Of Cardiovascular System

  • Cardiovascular Diseases
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Type 1 Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetes Mellitus Type 1

  • IDDM

  • Type 1 Diabetes

  • Insulin-Dependent Diabetes Mellitus

  • T1D

  • Juvenile-Onset Diabetes

  • Jod

  • Diabetes Mellitus, Type 1

  • Diabetes Mellitus, Insulin-Dependent-1

  • Type I Diabetes Mellitus

  • Autoimmune Diabetes

  • Juvenile Diabetes

  • Juvenile-Onset Diabetes Mellitus

  • Diabetes, Insulin Dependent

  • Insulin-Dependent Diabetes Mellitus-1

  • Diabetes Mellitus Insulin-Dependent

  • Diabetes Autoimmune

  • Diabetes Mellitus, Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 1, Susceptibility To

  • Diabetes Type 1

  • Type I Diabetes

  • Diabetes, Autoimmune

  • T1dm - [Type 1 Diabetes Mellitus]

  • Iddm - [Insulin Dependent Diabetes Mellitus]

  • Type 1 Iddm

  • Juvenile Diabetes Mellitus Without Compications

  • Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

  • Juvenile-Onset Diabetes Mellitus Without Compications

  • Ketosis-Prone Diabetes Mellitus Without Compications

  • Juvenile-Onset-Type Diabetes Mellitus Without Compications
Carotid Artery Disease

  • Carotid Artery Diseases

  • Disorder Of Carotid Artery
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Diabetes Mellitus

  • Diabetes
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Heart Disease

  • Heart Failure

  • Congenital Heart Disease

  • Heart Diseases

  • Congenital Heart Defects

  • Congenital Heart Defect

  • Heart Malformation

  • Congenital Anomaly Of Heart

  • Heart Defect

  • Heart-Congenital Defect

  • Congenital Heart Disorder

  • Heart Defects Congenital

  • Heart Defects, Congenital

  • Heart Defects

  • Heart Disease, Congenital

  • Disease, Heart, Congenital

  • Congestive Heart Failure
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-18540 KT109 Inhibitor 99.86% Unkown
HY-RS10634 PLA2G7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16659 Pla2g7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23094 Pla2g7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PLA2G7 MGD MGI:1351327
Felis catus PLA2G7 VGNC VGNC:68885
Rattus norvegicus PLA2G7 RGD RGD:1310734
Canis familiaris PLA2G7 VGNC VGNC:44632
Bos taurus PLA2G7 VGNC VGNC:32965
Macaca mulatta PLA2G7 VGNC VGNC:76158
Others PLA2G7 NCBI