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Cat. No.: HY-179060

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LAG-3 PROTAC-1

LAG-3 PROTAC-1 is a potent LAG-3 PROTAC degrader with a DC₅₀ of 0.27 μM. LAG-3 PROTAC-1 can be used in cancer immunology research.
(Pink: LAG-3 ligand (HY-179061); Blue: Cereblon ligand (HY-10984); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₃₄H₃₆N₆O₅
Masse moléculaire:608.69

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

LAG-3 PROTAC-1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

LAG-3 PROTAC-1 is a potent LAG-3 PROTAC degrader with a DC₅₀ of 0.27 μM. LAG-3 PROTAC-1 can be used in cancer immunology research^[1]. (Pink: LAG-3 ligand (HY-179061); Blue: Cereblon ligand (HY-10984); Black: linker).

IC₅₀ & Target^[1]

Cereblon

Voir tous les produits spécifiques à Isoform PROTACs :

Chemical Information

Masse moléculaire 608.69
Formule C₃₄H₃₆N₆O₅
SMILES

O=C(NCCCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)[C@H]([C@@H](C4=CC=CC=C4)C5)CN5CC6=CC=CC=N6
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Vázquez NG, et al. Design and validation of the first-in-class PROTACs for targeted degradation of the immune checkpoint LAG-3. Bioorg Med Chem Lett. 2025 Oct 4;130:130428. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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LAG-3 PROTAC-1

Voir tous les produits spécifiques à Isoform PROTACs

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

LAG-3 PROTAC-1 Related Classifications

HY-179060 Related Classifications