LDLRAP1-IN-1
Based on 1 Customer Validation
LDLRAP1-IN-1 (Compound B19) is a LDLRAP1 inhibitor and antiviral agent, with an IC50 of 4.98 μM for disrupting the interaction between LDLRAP1 and LDLR. LDLRAP1-IN-1 covalently modifies the C119 residue of LDLRAP1 at the LDLRAP1-LDLR binding interface, thereby disrupting the interaction between LDLRAP1 and LDLR. LDLRAP1-IN-1 exhibits antiviral activity against HCoV-OC43.
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- Pureté: 98.08%
- CAS No.: 3093624-24-6
- Formule: C21H14ClN5O4
- Masse moléculaire:435.82
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Anti-Infection Compound Library
HY-L002
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Metabolism/Protease Compound Library
HY-L012
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Antiviral Compound Library
HY-L027
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Metabolic Enzyme Compound Library
HY-L146
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Multi-Target Compound Library
HY-L176
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
Activité biologique
LDLRAP1-IN-1 (5 days potently inhibits HCoV-OC43 infection in Vero E6 cells with an EC50 of 1.0 ± 0.1 μM, while exhibiting low cytotoxicity (CC50 = 151 μM)[1].
LDLRAP1-IN-1 (1 h) disrupts the interaction between LDLRAP1 and LDLR, with an IC50 of 4.98 μM, and reduces the binding affinity by 11.1-fold[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3093624-24-6
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Appearance Solid
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Masse moléculaire 435.82
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Formule C21H14ClN5O4
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Color Light yellow to yellow
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SMILES
O=C(NC1=CC=C(N2N=CN=C2)C=C1)C3=CC([N+]([O-])=O)=CC=C3OC4=CC=C(Cl)C=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureté et documentation
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Fiche technique (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LDLRAP1-IN-1 Related Classifications
HY-181997 Related Classifications
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