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Cat. No.: HY-13475

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mPGES1-IN-8

mPGES1-IN-8, is a novel microsomal prostaglandin E synthase 1 (mPGES1) inhibitor.

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CAS No.: 1381846-21-4
Formule: C₁₆H₁₉ClN₄O₂
Masse moléculaire:334.80

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

mPGES1-IN-8 Chemical Structure

CAS No.: 1381846-21-4

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
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Activité biologique

Description

mPGES1-IN-8, is a novel microsomal prostaglandin E synthase 1 (mPGES1) inhibitor^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.87 μM Compound: 26	Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta by EIA method Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta by EIA method	[PMID: 26653180]

Chemical Information

CAS No. 1381846-21-4
Masse moléculaire 334.80
Formule C₁₆H₁₉ClN₄O₂
SMILES

O=C(NC1=NC=CN1)C2=CC(CNC(C(C)(C)C)=O)=CC=C2Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jin Y, et al. Dose-dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor. Br J Clin Pharmacol. 2018 Jan;84(1):179-188. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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mPGES1-IN-8

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Activité biologique

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mPGES1-IN-8 Related Classifications

HY-13475 Related Classifications