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Cat. No.: HY-148022

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NSC 330770

NSC 330770, a demethylated hydrogenated molecule, is a potent tubulin polymerization inhibitor (IC₅₀ of 2 μM). NSC 330770 elicites GTPase activity and the formation of abnormal polymers.

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CAS No.: 82585-91-9
Formule: C₁₆H₁₇N₅O₂
Masse moléculaire:311.34

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NSC 330770 Chemical Structure

CAS No.: 82585-91-9

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

NSC 330770, a demethylated hydrogenated molecule, is a potent tubulin polymerization inhibitor (IC₅₀ of 2 μM). NSC 330770 elicites GTPase activity and the formation of abnormal polymers^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	0.0047 μM Compound: 1	The compound was tested for cell growth inhibitory activity against lymphoid leukemia L1210 cell line. The compound was tested for cell growth inhibitory activity against lymphoid leukemia L1210 cell line.	[PMID: 2299631]
L1210	IC₅₀	0.0047 μM Compound: 29	Concentration required to inhibit 50% proliferation of cultured lymphoid leukemia L1210 cells was measured Concentration required to inhibit 50% proliferation of cultured lymphoid leukemia L1210 cells was measured	[PMID: 2231603]
L1210	IC₅₀	4.7 nM Compound: 1d	Inhibitory activity against lymphoid leukemia L1210 cells Inhibitory activity against lymphoid leukemia L1210 cells	[PMID: 2769680]
L1210	IC₅₀	4.7 nM Compound: 6	The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells	[PMID: 2795608]
L1210	IC₅₀	4.7 nM Compound: 6q	Cytotoxicity against lymphoid leukemia L1210 cells Cytotoxicity against lymphoid leukemia L1210 cells	[PMID: 1956035]

Chemical Information

CAS No. 82585-91-9
Masse moléculaire 311.34
Formule C₁₆H₁₇N₅O₂
SMILES

O=C(NC1=NC(N)=C2N=C(CNC2=C1)C3=CC=CC=C3)OCC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Barbier P, et al. Differential effects of ethyl 5-amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl carbamate analogs modified at position C2 on tubulin polymerization, binding, and conformational changes. Biochemistry. 1995 Dec 26;34(51):16821-9. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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