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Renadirsen sodium

(Synonyms: DS-5141b sodium)

Renadirsen sodium is an antisense oligonucleotide that induces robust Exon 45 skipping for Dystrophin in vivo.

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  • Renadirsen sodium Chemical Structure
    Renadirsen sodium Chemical Structure
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  • Renadirsen sodium Chemical Structure
    Renadirsen sodium Chemical Structure RNA, (P-thio)([2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-Gm-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5U-Gm-Cm-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-Am-Am-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5U-Gm-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-Am-Um-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C), 3'-[O-(2-hydroxyethyl) hydrogen phosphorothioate], sodium salt
    1/16
  • RNA, (P-thio)([2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-Gm-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5U-Gm-Cm-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-Am-Am-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5U-Gm-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-Am-Um-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C-(3'→4')-[2',6'-anhydro-5'-deoxy-4'-C-(hydroxymethyl)-α-L-lyxo-hexofurano]m5C), 3'-[O-(2-hydroxyethyl) hydrogen phosphorothioate], sodium salt