seco-CBI dimer
seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma.
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- CAS No.: 2592397-70-9
- Formule: C41H36Cl2N4O5
- Masse moléculaire:735.65
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Activité biologique
seco-CBI dimer-based ADCs potently inhibit the growth of CD22-positive lymphoma cells in vitro, with IC50 values ranging from 10 to 80 pM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2592397-70-9
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Masse moléculaire 735.65
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Formule C41H36Cl2N4O5
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SMILES
ClC[C@@H]1CN(C2=C1C3=C(C(O)=C2)C=CC=C3)C(/C=C/C4=C(C=C(C=C4)/C=C/C(N5C6=C([C@@H](C5)CCl)C7=C(C(O)=C6)C=CC=C7)=O)NC(CCN)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
seco-CBI dimer Related Classifications
HY-185488 Related Classifications
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