STAT3-IN-38
STAT3-IN-38 (Compound 4m) is an inhibitor of STAT3 (KD of rhSTAT3: 45.33 µM). STAT3-IN-38 binds to the SH2 domain of STAT3 protein and suppresses the STAT3’s phosphorylation at site pTyr705 as well as its downstream genes (Survivin and Mcl-1). STAT3-IN-38 could block cell-cycle and induce Apoptosis in colorectal cancer cells.
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- CAS No.: 3033049-16-7
- Formule: C35H45NO3S
- Masse moléculaire:559.80
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Activité biologique
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Chemical Information
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Activité biologique
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STAT3 45.33 μM (Kd) |
STAT3-IN-38 (0.5-1 μM, 6 h) inhibits the phosphorylation of STAT3 and decreases levels of the STAT3 target proteins survivin and myeloid cell leukemia 1 (Mcl-1) in HCT116 cells[1].
STAT3-IN-38 (0.02-12.5 μM, 48 h) inhibits the proliferation of A549, HCT116, and HepG2 cells[1].
STAT3-IN-38 (1-5 μM, 48 h) induces apoptosis and cell cycle arrest in HCT116 cells[1].
STAT3-IN-38 (1-10 µM, 6 days) reduces the viability of human colorectal cancer organoids (CCOs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116
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Concentration:1, 2.5, 5 μM
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Incubation Time:48 h
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Result:Delayed cell cycle distribution, with a leading cell cycle arrest in G2/M phase at low concentrations and in S and G2/M phases at high concentrations.
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Cell Line:A549、HCT-116、HepG2
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Concentration:0.02, 0.1, 0.5, 2.5, 12.5 μM
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Incubation Time:48 h
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Result:Inhibited the proliferation of A549, HCT116, and HepG2 cells (IC50s = 0.93, 0.61, and 1.79 µM, respectively).
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Cell Line:HCT-116
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Concentration:0.5, 0.75, 1 μM
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Incubation Time:6 h
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Result:Decreased the level of p-STAT3 at site pTyr705 in a concentration dependent manner, and the function was stronger than celastrol at 1.0 μM.
Down-regulated the level of Survivin and Mcl-1.
Chemical Information
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CAS No. 3033049-16-7
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Masse moléculaire 559.80
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Formule C35H45NO3S
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SMILES
C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)C(NCCC4=CC=CS4)=O)C)(CC[C@@]5(C2=CC=C6C5=CC(C(O)=C6C)=O)C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
STAT3-IN-38 Related Classifications
HY-169797 Related Classifications
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