3033049-16-7
3033049-16-7
Chemical Structure
STAT3-IN-38
- CAS No.: 3033049-16-7
- Formula:C35H45NO3S
- Molecular Weight:559.80
InChIKey: JKWCCKBBTJGQQC-GTKRWHGSSA-N
SMILES: C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)C(NCCC4=CC=CS4)=O)C)(CC[C@@]5(C2=CC=C6C5=CC(C(O)=C6C)=O)C)C
Biological Activity: STAT3-IN-38 (Compound 4m) is an inhibitor of STAT3 (KD of rhSTAT3: 45.33 µM). STAT3-IN-38 binds to the SH2 domain of STAT3 protein and suppresses the STAT3’s phosphorylation at site pTyr705 as well as its downstream genes (Survivin and Mcl-1). STAT3-IN-38 could block cell-cycle and induce Apoptosis in colorectal cancer cells[1].
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STAT3-IN-38 | STAT3-IN-38 (Compound 4m) is an inhibitor of STAT3 (KD of rhSTAT3: 45.33 µM). STAT3-IN-38 binds to the SH2 domain of STAT3 protein and suppresses the STAT3’s phosphorylation at site pTyr705 as well as its downstream genes (Survivin and Mcl-1). STAT3-IN-38 could block cell-cycle and induce Apoptosis in colorectal cancer cells. | |||||||||||||||||||||
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References
Keywords
