2. Anti-infection
  3. Bacterial
  4. D13-9001

D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively. D13-9001 exhibits antibiotic activities.

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D13-9001

D13-9001 Estructura química

No. CAS : 957471-96-4

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
1 mg En stock
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

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D13-9001 Related Antibodies

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Descripciòn

D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively[1]. D13-9001 exhibits antibiotic activities[2].

IC50 & Target

KD: 1.15 μM (AcrB), 3.57 μM (MexB)[1]
In Vitro

D13-9001 exhibits high solubility and a good safety profile[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D13-9001 Related Antibodies
In Vivo

D13-9001 (1.25-20 mg/kg; intravenous drip infusion; 2 hours) with aztreonam (AZT) gives improved survival rates in a lethal pneumonia rats at the end of day seven compared with AZT treated alone[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats (Pulmonary infection by P. aeruginosa PAM1020)[3]
Dosage: 1.25 mg/kg, 5 mg/kg, 20 mg/kg
Administration: Intravenous drip infusion; 2 hours
Result: The combination of 1.25, 5, and 20 mg/kg of D13-9001 with 1000 mg/kg of AZT gave improved survival rates at the end of day seven, whereas no obvious effect was observed on treatment with AZT alone.
Peso molecular

693.78

Fòrmula

C31H39N11O6S
No. CAS
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(NCC[N+](C)(CC([O-])=O)C)O[C@H]1CN(C(N=C2N3C=CC(C(NC4=NC(C(C)(C)C)=CS4)=O)=C2)=C(/C=C/C5=NN=NN5)C3=O)CCC1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (144.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4414 mL 7.2069 mL 14.4138 mL
5 mM 0.2883 mL 1.4414 mL 2.8828 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4414 mL 7.2069 mL 14.4138 mL 36.0345 mL
5 mM 0.2883 mL 1.4414 mL 2.8828 mL 7.2069 mL
10 mM 0.1441 mL 0.7207 mL 1.4414 mL 3.6034 mL
15 mM 0.0961 mL 0.4805 mL 0.9609 mL 2.4023 mL
20 mM 0.0721 mL 0.3603 mL 0.7207 mL 1.8017 mL
25 mM 0.0577 mL 0.2883 mL 0.5766 mL 1.4414 mL
30 mM 0.0480 mL 0.2402 mL 0.4805 mL 1.2011 mL
40 mM 0.0360 mL 0.1802 mL 0.3603 mL 0.9009 mL
50 mM 0.0288 mL 0.1441 mL 0.2883 mL 0.7207 mL
60 mM 0.0240 mL 0.1201 mL 0.2402 mL 0.6006 mL
80 mM 0.0180 mL 0.0901 mL 0.1802 mL 0.4504 mL
100 mM 0.0144 mL 0.0721 mL 0.1441 mL 0.3603 mL
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D13-9001 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D13-9001957471-96-4BacterialInhibitorinhibitorinhibit

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Nombre del producto:
D13-9001
Cat. No.:
HY-124819
Cantidad:
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