Synthesis of orotidine by intramolecular nucleosidation
- Chem Commun (Camb). 2015 Apr 4;51(26):5618-21. doi: 10.1039/c5cc00111k.
Affiliations
- 1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd, California. [email protected].
PMID: 25714895
DOI: 10.1039/c5cc00111k
Abstract
An intramolecular nucleosidation approach provides easy access to orotidine in high yields. Notably, orotate itself is used as a leaving group at the anomeric position. This method has the potential for facile access to derivatives of orotidine of therapeutic interest, with implications for prebiotic formation of nucleosides.
Products
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Cat. No.Product NameDescriptionTargetResearch Area
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target: Endogenous MetaboliteResearch Areas: Others