RIPK1-IN-23
RIPK1-IN-23 (compound 19) is a RIPK1 inhibitor with potent anti-necroptotic effects in HT-29 cells (EC50 of 1.7 nM). RIPK1-IN-23 shows anti-inflammatory activities.
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- CAS. Nr.: 3031534-16-1
- Formel: C27H22N6O3
- Molecular Weight:478.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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RIPK1 |
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Cell Line
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Type | Value | Description | References |
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| HT-29 | CC50 |
>100 μM
Compound: 19
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Cytotoxicity against human HT-29 cells by Cell Titer Glo assay
Cytotoxicity against human HT-29 cells by Cell Titer Glo assay
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[PMID: 38309200] |
| HT-29 | EC50 |
1.7 nM
Compound: 19
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Anti-necroptic activity against human HT-29 cells assessed as cell viability pretreated with compound followed by TNF-alpha/Smac mimetic/Z-VAD-FMK stimulation for 16 hrs by Cell Titer Glo assay
Anti-necroptic activity against human HT-29 cells assessed as cell viability pretreated with compound followed by TNF-alpha/Smac mimetic/Z-VAD-FMK stimulation for 16 hrs by Cell Titer Glo assay
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[PMID: 38309200] |
Chemical Information
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CAS. Nr. 3031534-16-1
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Molecular Weight 478.50
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Formel C27H22N6O3
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SMILES
CN1C([C@H](COC2=CC=C(C=C21)C3=CC=C(C=C3)C#N)NC(C4=NNC(CC5=CC=CC=C5)=N4)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
RIPK1-IN-23 Related Classifications
HY-157963 Related Classifications
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