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Art. -Nr.: HY-184739

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SMP-70067-L

SMP-70067-L (DL10) is a conjugate of a toxic molecule and a linker, in which the toxin moiety is Exatecan (HY-13631) and the linker moiety is SMP-93566-4-Leu-Cit-PAB-Glu (Ac) (HY-184740). SMP-70067-L can be used to synthesize the ADC SMP-70067-X.

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CAS. Nr.: 3120799-14-3
Formel: C₆₇H₈₂FN₁₃O₁₉
Molecular Weight:1392.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SMP-70067-L Chemical Structure

CAS. Nr.: 3120799-14-3

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Biologische Aktivität
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- In Vitro
Chemical Information
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Calculators
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Bioz

Biologische Aktivität

Beschreibung

Alle Drug-Linker Conjugates for ADC Isoform-spezifische Produkte anzeigen :

In Vitro

The drug-linker conjugates of antibody-drug conjugates (ADCs) consist of active cytotoxic drugs and appropriate linkers. After conjugation with monoclonal antibodies, these conjugates can be used to prepare ADCs, which are highly selective and cytotoxic targeted drugs against cancer cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3120799-14-3
Molecular Weight 1392.44
Formel C₆₇H₈₂FN₁₃O₁₉
SMILES

CC[C@]1(C(OCC2=C1C=C3C4=NC5=CC(F)=C(C6=C5C([C@H](CC6)NC(OCC7=CC=C(C=C7NC([C@@H](NC(C)=O)CCC(O)=O)=O)NC([C@@H](NC([C@H](C(C)C)NC(CN8CCOCCN(CCOCC8)C(CCN9C(C=CC9=O)=O)=O)=O)=O)CCCNC(N)=O)=O)=O)=C4CN3C2=O)C)=O)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Heng X, et al. An intrinsically hydrophilic linker enables a stable, high-DAR exatecan-based HER2 ADC with potent antitumor activity. European journal of medicinal chemistry. 2026 Oct 15;316:119054. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SMP-70067-L

Alle Drug-Linker Conjugates for ADC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

SMP-70067-L Related Classifications

HY-184739 Related Classifications