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AZ-TAK1

AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines.

For research use only. We do not sell to patients.

CAS No.: 1413440-36-4
Formula: C₂₅H₂₈FN₇O₂
Molecular Weight:477.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AZ-TAK1 Chemical Structure

CAS No.: 1413440-36-4

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Sample (0.1mg)

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(In Japan)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines^[1].

All MAP3K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
LoVo	IC₅₀	75 nM Compound: 2	Growth inhibition of human LoVo cells after 96 hrs by SRB assay Growth inhibition of human LoVo cells after 96 hrs by SRB assay	[PMID: 30576901]
SK-CO-1	IC₅₀	61 nM Compound: 2	Growth inhibition of human SKCO1 cells after 96 hrs by SRB assay Growth inhibition of human SKCO1 cells after 96 hrs by SRB assay	[PMID: 30576901]
SW-620	IC₅₀	38 nM Compound: 2	Growth inhibition of human SW620 cells after 96 hrs by SRB assay Growth inhibition of human SW620 cells after 96 hrs by SRB assay	[PMID: 30576901]

In Vitro

AZ-TAK1 (0.1μM) induces apoptosis in 28%, 24%, and 74% of Mino, SP53, and Jeko cells, respectively^[1].
AZ-TAK1 increases mitochondrial depolarization, indicated by a decrease in the red/green fluorescence intensity ratio^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1413440-36-4
Molecular Weight 477.53
Formula C₂₅H₂₈FN₇O₂
SMILES

FC1=C(C2=CN=C3C=CC=NN32)N=C(NC4=CC(OCCN5CCC(CC5)O)=CC(CC)=C4)N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Daniela Buglio, et al. Essential role of TAK1 in regulating mantle cell lymphoma survival. Blood. 2012 Jul 12;120(2):347-55. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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