Lipe - lipase, hormone sensitive Gene

Also Known as HSL; REH; 4933403G17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16890

Summary

Enables carboxylic ester hydrolase activity; protein kinase binding activity; and serine hydrolase activity. Involved in ether lipid metabolic process and lipid catabolic process. Acts upstream of or within cellular lipid catabolic process and cellular response to cold. Located in cytosol; lipid droplet; and membrane. Is expressed in adipose tissue; ileum; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (Lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Apr 2022]

Lipe Products (2)

mRNA Protein Name
NM_001039507.2 NP_001034596.1 hormone-sensitive lipase isoform 2
NM_010719.5 NP_034849.2 hormone-sensitive lipase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables diacylglycerol lipase activity IDA
IDA: Inferred from direct assay
23066022 MGI
enables monoacylglycerol lipase activity IDA
IDA: Inferred from direct assay
21454566 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19717842 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15878856 MGI
enables retinyl-palmitate esterase activity IDA
IDA: Inferred from direct assay
15550674 MGI
enables serine hydrolase activity IDA
IDA: Inferred from direct assay
16818490 MGI
enables sterol ester esterase activity IDA
IDA: Inferred from direct assay
15550674 MGI
enables triacylglycerol lipase activity IDA
IDA: Inferred from direct assay
15550674 MGI
enables triacylglycerol lipase activity IMP
IMP: Inferred from mutant phenotype
17074755 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to cold IDA
IDA: Inferred from direct assay
30862682 MGI
acts upstream of or within diacylglycerol catabolic process IDA
IDA: Inferred from direct assay
16804080 MGI
involved in diacylglycerol catabolic process IDA
IDA: Inferred from direct assay
23066022 MGI
acts upstream of or within diacylglycerol catabolic process IMP
IMP: Inferred from mutant phenotype
11717312 MGI
involved in ether lipid metabolic process IDA
IDA: Inferred from direct assay
20625037 MGI
involved in lipid catabolic process IDA
IDA: Inferred from direct assay
15878856 MGI
acts upstream of or within long-chain fatty acid catabolic process IDA
IDA: Inferred from direct assay
16804080 MGI
acts upstream of or within triglyceride catabolic process IDA
IDA: Inferred from direct assay
16804080 MGI
acts upstream of or within triglyceride catabolic process IMP
IMP: Inferred from mutant phenotype
11717312 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
15550674 MGI
located in lipid droplet IDA
IDA: Inferred from direct assay
15878856 MGI
located in membrane IDA
IDA: Inferred from direct assay
15550674 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hormone-sensitive lipase

  • monoacylglycerol lipase LIPE

  • retinyl ester hydrolase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112083 BAY-3827 Inhibitor 99.72% Unkown
HY-153523 Hi 76-0079 Inhibitor 99.87% Unkown
HY-RS07687 LIPE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18621 Lipe Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25107 Lipe Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lipe NCBI NCBI:3991