ARFGAP3 - ADP ribosylation factor GTPase activating protein 3 Gene

Also Known as ARFGAP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26286

About ARFGAP3

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:42,796,502-42,857,273 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 28 paralogues. Ubiquitous expression in adrenal (RPKM 47.6), prostate (RPKM 36.1) and 25 other tissues.

Summary

The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to Phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]

ARFGAP3 Products (2)

mRNA	Protein	Name
NM_001142293.2	NP_001135765.1	ADP-ribosylation factor GTPase-activating protein 3 isoform 2
NM_014570.5	NP_055385.3	ADP-ribosylation factor GTPase-activating protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	11172815	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23275563	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein secretion	IEP IEP: Inferred from expression pattern	11172815	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	11172815	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARFGAP3 Protein Structure

ArfGap

0
100
200
300
400
516 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylation factor GTPase-activating protein 3	ADP-ribosylation factor GTPase activating protein 1

ARFGAP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARFGAP3	Q9NP61	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	BACE2	Homo sapiens	Q9Y5Z0	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	BACE2	Homo sapiens	Q9Y5Z0	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	BACE2	Homo sapiens	Q9Y5Z0	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	SYPL1	Homo sapiens	Q16563	Y2H Prey Pooling	32296183
Intra	ARFGAP3	Q9NP61	SYPL1	Homo sapiens	Q16563	Y2H Array	32296183
Intra	ARFGAP3	Q9NP61	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	ARFGAP3	Q9NP61	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	ARFGAP3	Q9NP61	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	SERPINH1	Homo sapiens	P50454	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	SERPINH1	Homo sapiens	P50454	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	SERPINH1	Homo sapiens	P50454	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	CCT5	Homo sapiens	P48643	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	HTT	Homo sapiens	P42858	Lumier	23275563
Intra	ARFGAP3	Q9NP61	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	ARFGAP3	Q9NP61	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Intra	ARFGAP3	Q9NP61	PTGS1	Homo sapiens	P23219	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	PTGS1	Homo sapiens	P23219	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	PTGS1	Homo sapiens	P23219	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	RAD23A	Homo sapiens	P54725	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	RAD23A	Homo sapiens	P54725	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	RAD23A	Homo sapiens	P54725	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	NDUFV1	Homo sapiens	P49821	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	NDUFV1	Homo sapiens	P49821	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	NDUFV1	Homo sapiens	P49821	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	CDH1	Homo sapiens	A5D8W4	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	CDH1	Homo sapiens	A5D8W4	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	CDH1	Homo sapiens	A5D8W4	Y2H Array	32814053
Intra	ARFGAP3	Q9NP61	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
Intra	ARFGAP3	Q9NP61	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	ARFGAP3	Q9NP61	PEX1	Homo sapiens	O43933	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ceroid Lipofuscinosis, Neuronal, 4	Ceroid Lipofuscinosis, Neuronal, Parry Type Cln4b Disease Neuronal Ceroid Lipofuscinosis 4b CLN4B Autosomal Dominant Neuronal Ceroid Lipofuscinosis 4b Ceroid Lipofuscinosis, Neuronal, 4b, Autosomal Dominant Adult Neuronal Ceroid Lipofuscinosis CLN4 Ceroid Lipofuscinosis, Neuronal, 4 , Autosomal Dominant Neuronal Ceroid Lipofuscinosis 4 Neuronal Ceroid Lipofuscinosis 4 Parry Type Adult Neuronal Ceroid Lipofuscinosis 4b Kuf'S Disease Type B Kuf'S Disease, Autosomal Dominant Cln4 Disease Parry Disease Ceroid Lipofuscinosis, Neuronal 4 Ceroid Lipofuscinosis, Neuronal, 4b , Autosomal Dominant Kufs Disease Autosomal Dominant Neuronal Ceroid Lipofuscinosis Parry Type Ceroid Lipofuscinosis, Neuronal, 4, Parry Type Lipofuscinosis, Ceroid, Neuronal, Type 4, Parry Type
Hypotrichosis-Lymphedema-Telangiectasia Syndrome	HLTS Hypotrichosis Lymphedema Telangiectasia Syndrome Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Hypersensitivity Reaction Type Iv Disease	Immunoproliferative Disorders Immunoproliferative Disease
Pelvic Organ Prolapse	Rectal Prolapse Pelvic Organ Prolapse, Susceptibility To, 1 Pelvic Organ Prolapse, Susceptibility To Prolapse Of Vagina And Rectum Vaginal Prolapse Pelvic Organ Prolapse 1 Procidentia, Rectum Prolapse Of Rectal Mucosa Procidentia Of Rectum Rectal Mucosa Prolapse Rectum Prolapse Procidentia Rectum Rp - [Rectal Prolapse] Male Proctocele Male Rectocele Proctoptosis Female Genital Prolapse Female Prolapse Incompetence Of Pelvic Fundus Relaxation Of Perineum Deficiency Of Perineum
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00901	ARFGAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21984	Arfgap3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28502	Arfgap3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARFGAP3	VGNC	VGNC:38034
Rattus norvegicus	ARFGAP3	RGD	RGD:1560066
Bos taurus	ARFGAP3	VGNC	VGNC:26063
Mus musculus	ARFGAP3	MGD	MGI:1913501
Macaca mulatta	ARFGAP3	VGNC	VGNC:70002
Felis catus	ARFGAP3	VGNC	VGNC:68050
Others	ARFGAP3	NCBI