FCRL5 - Fc receptor like 5 Gene

Also Known as CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83416

About FCRL5

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:157,513,377-157,552,515 (from NCBI)

This gene has 8 transcripts (splice variants), 83 orthologues and 17 paralogues. Biased expression in lymph node (RPKM 14.3), spleen (RPKM 11.3) and 8 other tissues.

Summary

This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several Other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]

FCRL5 Products (2)

mRNA Protein Name
NM_001195388.2 NP_001182317.1 Fc receptor-like protein 5 isoform 2 precursor
NM_031281.3 NP_112571.2 Fc receptor-like protein 5 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
30107486 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in B cell activation IDA
IDA: Inferred from direct assay
30107486 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
16849395 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
16849395 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCRL5 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (27 - 96)

Ig_2

Ig_2: Immunoglobulin domain (107 - 185)

Ig_2

Ig_2: Immunoglobulin domain (192 - 273)

Ig_2

Ig_2: Immunoglobulin domain (287 - 373)

Ig_2

Ig_2: Immunoglobulin domain (380 - 466)

Ig_2

Ig_2: Immunoglobulin domain (473 - 559)

Ig_3

Ig_3: Immunoglobulin domain (565 - 638)

Ig_3

Ig_3: Immunoglobulin domain (658 - 731)

Ig_2

Ig_2: Immunoglobulin domain (755 - 835)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 977 a.a.
Protein Preferred Names Protein Names

Fc receptor-like protein 5

  • fc receptor homolog 5

FCRL5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FCRL5 Q96RD9 CAGE1 Homo sapiens Q8TC20-4
Y2H Array
32296183
Intra
FCRL5 Q96RD9 CAGE1 Homo sapiens Q8TC20-4
Y2H Prey Pooling
32296183
Intra
FCRL5 Q96RD9 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra
FCRL5 Q96RD9 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
Intra
FCRL5 Q96RD9 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra
FCRL5 Q96RD9 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra
FCRL5 Q96RD9 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FCRL5 Proteins

Cat. No. Product Name Accession Purity
HY-P700302 FcRH5/FcRL5 Protein, Human (HEK293, His) Q96RD9-1 (Q16-G851) > 95%, as determined by Bis-Tris PAGE.

FCRL5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84739 CD307E Antibody (YA4436) ICC/IF, FC, ELISA Human
HY-P84739A CD307E Antibody (YA4436)(PBS only) ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Hairy Cell Leukemia

  • Hcl-V

  • Hairy Cell Leukemia Variant

  • Hairy Cell Leukaemia Variant

  • Hcl

  • Leukemic Reticuloendotheliosis

  • Leukemic Reticuloendotheliosis Variant

  • Prolymphocytic Variant Of Hcl

  • Prolymphocytic Variant Of Hairy Cell Leukemia

  • Leukemia Hairy Cell

  • Leukemia, Hairy Cell

  • Leukaemic Reticuloendotheliosis

  • Lre - [Leukemic Reticuloendotheliosis]

  • Hairy-Cell Leukaemia, Nos

  • Hcl - [Hairy Cell Leukaemia]

  • Hairy-Cell Leukaemia Without Mention Of Remission
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Burkitt Lymphoma

  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160799 HA-9104 Inducer 98.58% Unkown
HY-RS04846 FCRL5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19193 Fcrl5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25681 Fcrl5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FCRL5 RGD RGD:1589379
Bos taurus FCRL5 VGNC VGNC:59181
Canis familiaris FCRL5 VGNC VGNC:49722
Felis catus FCRL5 VGNC VGNC:62216
Macaca mulatta FCRL5 VGNC VGNC:99950
Mus musculus FCRL5 MGD MGI:3053558
Others FCRL5 NCBI