CD307E Antibody (YA4436)
(Synonyms: FCRL5; CD307; FCRH5; IRTA2; BXMAS1; PRO820)CD307E Antibody (YA4436) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD307E.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
CD307E Antibody (YA4436) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD307E.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 106 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 106.4 kDa
Purified recombinant fragment of human CD307E (AA: extra 16-158) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD307E plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation. May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization[1].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level) -
Isoforms & Post-Translational Modification
Q96RD9 has 5 isomers: Q96RD9-1: 106437 Da (predicted); Q96RD9-2: 14080 Da (predicted); Q96RD9-3: 83293 Da (predicted); Q96RD9-4: 65617 Da (predicted); Q96RD9-5: 17377 Da (predicted).
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Subunit
Interacts with CR2 (PubMed:30107486). Interacts with CD19 (PubMed:30107486)
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SwissProt ID
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Synonyms
FCRL5; CD307; FCRH5; IRTA2; BXMAS1; PRO820
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