Ihh - Indian hedgehog signaling molecule Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84399

Summary

Predicted to enable calcium ion binding activity and patched binding activity. Involved in several processes, including liver regeneration; maternal process involved in female pregnancy; and response to estradiol. Predicted to be located in extracellular matrix and plasma membrane. Predicted to be active in extracellular space. Biomarker of osteoarthritis. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian Hedgehog signaling molecule). [provided by Alliance of Genome Resources, Apr 2022]

Ihh Products (1)

mRNA Protein Name
NM_053384.1 NP_445836.1 indian hedgehog protein precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in liver regeneration IEP
IEP: Inferred from expression pattern
22024090 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
18612197 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16488438 RGD
involved in positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16488438 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17109907 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
15111639 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

indian hedgehog protein

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0338A Rimantadine hydrochloride 98.0% Unkown
HY-B0338 Rimantadine 99.86% Unkown

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N17821 Butrin / Unkown
HY-RS06654 IHH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17797 Ihh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24265 Ihh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992409 MEDI-5304 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ihh NCBI NCBI:3549