Rimantadine hydrochloride
Based on 1 publication(s) in Google Scholar
Rimantadine hydrochloride (Flumadine hydrochloride) is an orally active inhibitor for M2 protein, that blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1501-84-4
- Formula: C12H22ClN
- Molecular Weight:215.76
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Rimantadine hydrochloride
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Biological Activity
Rimantadine hydrochloride (0-10 μg/mL, 72 h) inhibits the RNA levels of hepatitis A virus (HAV) in Huh7 and IHH cells with IC50 of 6.7 and 1.6 μg/mL[1].
Rimantadine hydrochloride (0-10 μg/mL, 72 h) increases the expression of the autophagy marker LC3, inhibits the phosphorylation of mTOR, increases the number of lysosomes, and promotes autophagy in HAV-infected Huh7 cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HAV-infected Huh7 cell
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Concentration:0-10 μg/mL
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Incubation Time:72 h
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Result:Induced autophagy.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:H3N2-infected mouse models[2]
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Dosage:20-80 mg/kg (combined with 0.8-3.2 mg/kg oseltamivir)
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Administration:po for 5 days
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Result:Lowered the lung virus titer.
Chemical Information
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CAS No. 1501-84-4
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Appearance Solid
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Molecular Weight 215.76
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Formula C12H22ClN
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Color White to off-white
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SMILES
CC(C1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1)N.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 50 mg/mL (231.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 33.33 mg/mL (154.48 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 33.33 mg/mL (154.48 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Sasaki-Tanaka R, et al., Amantadine and Rimantadine Inhibit Hepatitis A Virus Replication through the Induction of Autophagy. J Virol. 2022 Sep 28;96(18):e0064622. [Content Brief]
[2]. Simeonova L, et al., Prophylactic and therapeutic combination effects of rimantadine and oseltamivir against influenza virus A (H3N2) infection in mice. Antiviral Res. 2012 Aug;95(2):172-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 4.6348 mL | 23.1739 mL | 46.3478 mL | 115.8695 mL |
| 5 mM | 0.9270 mL | 4.6348 mL | 9.2696 mL | 23.1739 mL | |
| 10 mM | 0.4635 mL | 2.3174 mL | 4.6348 mL | 11.5869 mL | |
| 15 mM | 0.3090 mL | 1.5449 mL | 3.0899 mL | 7.7246 mL | |
| 20 mM | 0.2317 mL | 1.1587 mL | 2.3174 mL | 5.7935 mL | |
| 25 mM | 0.1854 mL | 0.9270 mL | 1.8539 mL | 4.6348 mL | |
| 30 mM | 0.1545 mL | 0.7725 mL | 1.5449 mL | 3.8623 mL | |
| 40 mM | 0.1159 mL | 0.5793 mL | 1.1587 mL | 2.8967 mL | |
| 50 mM | 0.0927 mL | 0.4635 mL | 0.9270 mL | 2.3174 mL | |
| 60 mM | 0.0772 mL | 0.3862 mL | 0.7725 mL | 1.9312 mL | |
| 80 mM | 0.0579 mL | 0.2897 mL | 0.5793 mL | 1.4484 mL | |
| 100 mM | 0.0463 mL | 0.2317 mL | 0.4635 mL | 1.1587 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Rimantadine hydrochloride Related Classifications
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