PYGO2 - pygopus family PHD finger 2 Gene

Also Known as 1190004M21Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90780

About PYGO2

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,957,026-154,961,782 (from NCBI)

This gene has 3 transcripts (splice variants), 177 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 16.3), ovary (RPKM 15.1) and 25 other tissues.

Summary

Predicted to enable several functions, including chromatin binding activity; Histone Acetyltransferase regulator activity; and histone binding activity. Predicted to be involved in kidney development and spermatid nucleus differentiation. Predicted to act upstream of or within several processes, including animal organ development; positive regulation of chromatin binding activity; and regulation of histone H3-K4 methylation. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]

PYGO2 Products (1)

mRNA Protein Name
NM_138300.4 NP_612157.1 pygopus homolog 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17113272 GOA
Cellular Component GO Annotation Evidence References Source
part of beta-catenin-TCF complex IDA
IDA: Inferred from direct assay
28296634 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PYGO2 Protein Structure

PHD

PHD: PHD-finger (330 - 383)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

pygopus homolog 2

  • pygopus 2

PYGO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PYGO2 Q9BRQ0 BCL9 Homo sapiens O00512
TAP
24981860
Intra
PYGO2 Q9BRQ0 SORCS3 Homo sapiens Q9UPU3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

PYGO2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83103 PYGO2 Antibody (YA2848) WB, IHC-P, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Oligospermia
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-157891 JBC117 Inducer 99.71% Unkown
HY-RS11492 PYGO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PYGO2 VGNC VGNC:33591
Rattus norvegicus PYGO2 RGD RGD:1308535
Felis catus PYGO2 VGNC VGNC:107926
Macaca mulatta PYGO2 VGNC VGNC:76569
Canis familiaris PYGO2 VGNC VGNC:45227
Mus musculus PYGO2 MGD MGI:1916161
Others PYGO2 NCBI