SORCS3 - sortilin related VPS10 domain containing receptor 3 Gene

Homo sapiens

Also known as SORCS

Gene ID: 22986 | Gene type: protein coding

About SORCS3

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:104,641,290-105,265,242 (from NCBI)

This gene has 2 transcripts (splice variants), 422 orthologues and 4 paralogues. Biased expression in brain (RPKM 4.8), adrenal (RPKM 1.2) and 1 other tissue.

Summary

This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in Cell Culture results in an increase in amyloid precursor protein processing. [provided by RefSeq, Dec 2014]

SORCS3 Products(1)

mRNA	Protein	Name
NM_014978.3	NP_055793.1	VPS10 domain-containing receptor SorCS3 precursor

SORCS3 Protein Structure

PKD

0
100
197 a.a.

Protein Preferred Names

Protein Names

VPS10 domain-containing receptor SorCS3

VPS10 domain receptor protein SORCS 3 (SORCS3)

Related Diseases

Diseases

Alias

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13572	SORCS3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SORCS3	MGD	MGI:1913923
Canis familiaris	SORCS3	VGNC	VGNC:46661
Felis catus	SORCS3	VGNC	VGNC:65573
Macaca mulatta	SORCS3	VGNC	VGNC:77934
Rattus norvegicus	SORCS3	RGD	RGD:1310974
Bos taurus	SORCS3	VGNC	VGNC:106943

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