NR1H4 - nuclear receptor subfamily 1 group H member 4 Gene

Also Known as BAR; FXR; HRR1; HRR-1; PFIC5; RIP14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9971

About NR1H4

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:100,473,866-100,564,414 (from NCBI)

This gene has 11 transcripts (splice variants), 388 orthologues, 18 paralogues and is associated with 3 phenotypes. Biased expression in liver (RPKM 14.7), small intestine (RPKM 8.3) and 6 other tissues.

Summary

This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]

NR1H4 Products (12)

mRNA	Protein	Name
NM_005123.4	NP_005114.1	bile acid receptor isoform 2
NR_135146.2
NM_001206979.2	NP_001193908.1	bile acid receptor isoform 1
XM_006719719.3	XP_006719782.1	bile acid receptor isoform X4
XM_011539040.3	XP_011537342.1	bile acid receptor isoform X1
NM_001206977.2	NP_001193906.1	bile acid receptor isoform 1
NM_001206978.2	NP_001193907.1	bile acid receptor isoform 5
NM_001206993.2	NP_001193922.1	bile acid receptor isoform 3
NM_001206992.2	NP_001193921.1	bile acid receptor isoform 4
XM_047429943.1	XP_047285899.1	bile acid receptor isoform X2
XM_047429944.1	XP_047285900.1	bile acid receptor isoform X5
XM_011539041.3	XP_011537343.1	bile acid receptor isoform X3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21757002	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21757002	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21757002	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23767959	GOA
enables bile acid binding	IDA IDA: Inferred from direct assay	21757002	GOA
enables bile acid nuclear receptor activity	IDA IDA: Inferred from direct assay	10334992	GOA
enables chenodeoxycholic acid binding	IDA IDA: Inferred from direct assay	10334992	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	27471003	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12917342	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12815072	GOA
enables transcription cis-regulatory region binding	IMP IMP: Inferred from mutant phenotype	26888176	GOA
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	14701856	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to bile acid	IDA IDA: Inferred from direct assay	10334992	GOA
involved in cellular response to bile acid	IMP IMP: Inferred from mutant phenotype	23767959	GOA
involved in cellular response to fatty acid	IDA IDA: Inferred from direct assay	20447400	GOA
involved in intracellular triglyceride homeostasis	IDA IDA: Inferred from direct assay	20447400	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	20447400	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	21242261	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	21242261	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	21242261	GOA
acts upstream of or within negative regulation of very-low-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	27471003	GOA
involved in nuclear receptor-mediated bile acid signaling pathway	IDA IDA: Inferred from direct assay	10334992	GOA
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	27471003	GOA
involved in positive regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	21242261	GOA
involved in positive regulation of phosphatidic acid biosynthetic process	IDA IDA: Inferred from direct assay	23767959	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23767959	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21757002	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	26888176	GOA
involved in regulation of insulin secretion involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	20447400	GOA
involved in regulation of low-density lipoprotein particle clearance	IDA IDA: Inferred from direct assay	12660231	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10334992	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in euchromatin	IDA IDA: Inferred from direct assay	21757002	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	10334992	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR1H4 Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
486 a.a.

Protein Preferred Names	Protein Names
bile acid receptor	RXR-interacting protein 14 farnesoid X nuclear receptor farnesoid X-activated receptor farnesol receptor HRR-1 retinoid X receptor-interacting protein 14

NR1H4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NR1H4	Q96RI1	PHF2	Homo sapiens	O75151	Pull Down	21532585
Intra	NR1H4	Q96RI1	SETD7	Homo sapiens	Q8WTS6	Y2H	22345554
Intra	NR1H4	Q96RI1	SETD7	Homo sapiens	Q8WTS6	Anti Bait CoIP	22345554
Intra	NR1H4	Q96RI1	SETD7	Homo sapiens	Q8WTS6	Pull Down	22345554
Intra	NR1H4	Q96RI1	SETD7	Homo sapiens	Q8WTS6	Methyltransferase Ass	22345554
Intra	NR1H4	Q96RI1	NCOA1	Homo sapiens	Q15788	HTRF	14684751
Intra	NR1H4	Q96RI1	NCOA1	Homo sapiens	Q15788	Pull Down	14684751

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Biliary Tract Disease	Biliary Tract Diseases Biliary Tract Abnormality
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases Cardiovascular Disease
Cholestasis	Obstruction Of Bile Duct Bile Duct Obstruction Bile Occlusion Extrahepatic Biliary Obstruction Extrahepatic Bile Duct Obstruction Bile Stasis Biliary Stasis Obstructive Hyperbilirubinemia Obstructed Jaundice Bile Duct Obstructed Bile Ductal Obstruction Biliary Duct Obstruction Obstructed Bile Ductal Obstructed Biliary Duct Obstructed Biliary Ductal Jaundice Regurgitation Obstructive Jaundice Cholestatic Jaundice Cholestatic Jaundice Syndrome
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Lysosomal Storage Disease	Lysosomal Storage Diseases Disorder Of Lysosomal Enzyme Inborn Lysosomal Enzyme Disorder Lysosomal Storage Metabolism Disorder Lysosomal Storage Disorder
Osteogenesis Imperfecta, Type Xiii	Osteogenesis Imperfecta Type 13 OI13 Osteogenesis Imperfecta Type Xiii Oi, Type Xiii Osteogenesis Imperfecta 13 Oi Type Xiii Oi-Xiii
Cholangitis	Acute Cholangiolitis Ascending Cholangitis Cholangiolitis Cholangitis Nos Chronic Cholangiolitis Hepatic Duct Inflammation Acute Cholangitis Bile Duct Inflammation
Leber Congenital Amaurosis 7	LCA7 Leber Congenital Amaurosis, Type 7
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Cholestasis, Progressive Familial Intrahepatic, 5	PFIC5 Progressive Familial Intrahepatic Cholestasis 5 Nr1h4 Deficiency Progressive Familial Intrahepatic Cholestasis Type 5 Cholestasis, Intrahepatic, Familial, Progressive, Type 5
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Bile Duct Disease	Bile Duct Diseases Bile Duct Disorder Disorder Of Bile Duct
Functional Diarrhea	Functional Diarrhoea
Cholestasis, Progressive Familial Intrahepatic, 2	PFIC2 Cholestasis, Progressive Familial Intrahepatic 2 Progressive Familial Intrahepatic Cholestasis Type 2 Progressive Familial Intrahepatic Cholestasis 2 Bsep Deficiency Recurrent Familial Intrahepatic Cholestasis 2 Benign Recurrent Intrahepatic Cholestasis 2 Severe Abcb11 Deficiency Bric2 Cholestasis, Benign Recurrent Intrahepatic 2 Mild Abcb11 Deficiency Cholestasis, Intrahepatic, Familial, Progressive, Type 2
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Diabetes Mellitus	Diabetes
Hypercholesterolemia, Familial, 1	Hypercholesterolemia FHCL1 Fhc Fh Hyperlipoproteinemia, Type Ii Hyperlipoproteinemia, Type Iia Hyper-Low-Density-Lipoproteinemia Hypercholesterolemic Xanthomatosis, Familial Ldl Receptor Disorder Hypercholesterolemia, Susceptibility To Hypercholesterolemia, Familial, Modifier Of Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of Ldl Cholesterol Level Qtl2 Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial, Type 1 High Cholesterol Increased Cholesterol Low-Density-Lipoid-Type Hyperlipoproteinemia Pure Hypercholesterolaemia Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia Group A Hyperlipidaemia Pure Hypercholesterinaemia Cholesterolaemia Essential Cholesterolaemia Essential Hypercholesterolaemia Group A Hyperlipemia Increased Low Density Lipoprotein Low-Density-Lipoprotein-Type Low-Density-Lipoprotein-Type Hyperlipoproteinemia
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Cholelithiasis
Abdominal Obesity-Metabolic Syndrome 1	Metabolic Syndrome X Metabolic Syndrome AOMS1 Dysmetabolic Syndrome X Metabolic Disease Abdominal Obesity Metabolic Syndrome
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Cerebrotendinous Xanthomatosis	CTX Cerebral Cholesterinosis Cholestanol Storage Disease Xanthomatosis, Cerebrotendinous Sterol 27-Hydroxylase Deficiency Xanthomatosis Cerebrotendinous Cerebrotendinous Cholesterinosis Cholestanolosis Van Bogaert-Scherer-Epstein Disease
Trimethylaminuria	TMAU Fish-Odor Syndrome Fish Malodor Syndrome Fish Odor Syndrome Stale Fish Syndrome Tmauria Severe Primary Trimethylaminuria Mesh D008661 Fish Odour Syndrome
Sclerosing Cholangitis	Fibrosing Cholangitis Cholangitis, Sclerosing Primary Sclerosing Cholangitis
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Non-Alcoholic Steatohepatitis	Nonalcoholic Steatohepatitis Nash Nash - [Non-Alcoholic Steatohepatitis] Non-Alcoholic Steatohepatosis
Pericholangitis
Barrett Esophagus	Barrett Esophagus/Esophageal Adenocarcinoma Barrett'S Esophagus Barrett Metaplasia Barrett'S Ulcer Of Esophagus Ulcerative Esophagitis Barrett'S Esophagus With Esophagitis Barrett'S Oesophagus Barretts Syndrome Barrett Syndrome BE Peptic Ulcer Of Esophagus Adenocarcinoma Of Esophagus
Biliary Atresia	Congenital Biliary Atresia Isolated Biliary Atresia Isolated Atresia Of Bile Ducts Non-Syndromic Biliary Atresia Atresia Of Bile Duct Biliary Atresia, Congenital Atresia Of Bile Ducts Bile Duct Atresia Congenital Bile Duct Atresia Ba - [Biliary Atresia] Impervious Bile Duct Atresia Of Common Duct Biliary Duct Atresia Bile Ductal Atresia Cystic Duct Atresia
Intrahepatic Cholestasis Of Pregnancy	Recurrent Intrahepatic Cholestasis Of Pregnancy Gravidic Intrahepatic Cholestasis Pregnancy-Related Cholestasis Icp Pregnancy Related Cholestasis Cholestasis, Intrahepatic Of Pregnancy Familial Intrahepatic Cholestasis Of Pregnancy Familial Recurrent Intrahepatic Cholestasis Of Pregnancy Ricp Obstetric Cholestasis
Autoimmune Disease Of Gastrointestinal Tract
Hepatic Vascular Disease	Vascular Disorder Of Liver
Cholestasis, Benign Recurrent Intrahepatic, 1	Benign Recurrent Intrahepatic Cholestasis BRIC1 Summerskill Syndrome Bric Summerskill-Walshe-Tygstrup Syndrome Cholestasis, Benign Recurrent Intrahepatic Benign Recurrent Intrahepatic Cholestasis 1 Benign Recurrent Intrahepatic Cholestasis Type 1 Bric Type 1 Low Gamma-Gt Familial Intrahepatic Cholestasis Recurrent Familial Intrahepatic Cholestasis Cholestasis, Benign Recurrent Intrahepatic 1 Mild Atp8b1 Deficiency Recurrent Familial Intrahepatic Cholestasis 1 Abcb11-Related Intrahepatic Cholestasis Atp8b1-Related Intrahepatic Cholestasis Cholestasis, Intrahepatic, Recurrent, Benign, Type 1 Progressive Intrahepatic Cholestasis Cholestasis, Progressive Familial Intrahepatic 3 Bric - [Benign Recurrent Intrahepatic Cholestasis]
Bile Reflux
Arthrogryposis, Distal, Type 1c	DA1C Distal Arthrogryposis Type 1c Arthrogryposis, Distal, 1c
Cholestasis, Benign Recurrent Intrahepatic, 2	BRIC2 Benign Recurrent Intrahepatic Cholestasis 2 Benign Recurrent Intrahepatic Cholestasis Type 2 Bric Type 2 Cholestasis, Intrahepatic, Recurrent, Benign, Type 2 Cholestasis, Benign Recurrent Intrahepatic 2
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Cholestasis, Progressive Familial Intrahepatic, 4	PFIC4 Progressive Familial Intrahepatic Cholestasis 4 Cholestasis, Progressive Familial Intrahepatic 4 Tjp2 Deficit Progressive Familial Intrahepatic Cholestasis-4 3-Beta-Hydroxy-Delta-5-C27-Steroid Oxidoreductase Deficiency Progressive Familial Intrahepatic Cholestasis Type 4 Cholestasis, Intrahepatic, Familial, Progressive, Type 4 Bile Acid Synthesis Defect, Congenital, 1
Cholestasis, Progressive Familial Intrahepatic, 1	PFIC1 Byler Disease Cholestasis, Progressive Familial Intrahepatic 1 Progressive Familial Intrahepatic Cholestasis 1 Progressive Familial Intrahepatic Cholestasis Type 1 Fic1 Deficiency Byler'S Disease Cholestasis, Fatal Intrahepatic Progressive Familial Intrahepatic Cholestasis Severe Atp8b1 Deficiency Fatal Intrahepatic Cholestasis Cholestasis, Intrahepatic, Familial, Progressive, Type 1 Progressive Intrahepatic Cholestasis Cholestasis, Progressive Familial Intrahepatic 3
Xanthomatosis	Xanthomatosis, Susceptibility To Xanthelasmatosis
Choline Deficiency Disease	Choline Deficiency
Lipid Storage Disease	Lipoidosis Inborn Lipid Storage Disorder Lipoid Storage Diseas Lipid Storage Diseases Lipidoses
Portal Hypertension	Hypertension, Portal Hypertension Portal Pht - [Portal Hypertension] Portal Htn
Alcoholic Hepatitis	Acute Alcoholic Hepatitis Acute Alcoholic Liver Disease Hepatitis, Alcoholic Hepatitis Alcoholic Ah - [Alcoholic Hepatitis] Ethanol Hepatitis
Progressive Familial Intrahepatic Cholestasis	Abcb4-Related Intrahepatic Cholestasis Cholestasis, Progressive Familial Intrahepatic Pfic Byler Disease Abcb11-Related Intrahepatic Cholestasis Atp8b1-Related Intrahepatic Cholestasis Bsep Deficiency Byler Disease Byler Syndrome Fic1 Deficiency Low Γ-Gt Familial Intrahepatic Cholestasis Mdr3 Deficiency Pfic Cholestasis, Intrahepatic, Familial, Progressive Pfic - [Progressive Familial Intrahepatic Cholestasis]
Hepatocellular Clear Cell Carcinoma	Clear Cell Carcinoma Of The Liver Cells Hepatocellular Carcinoma, Clear Cell Type Clear Cell Hepatocellular Carcinoma
Extrahepatic Cholestasis	Cholestasis, Extrahepatic Extrahepatic Biliary Stasis Extrahepatic Obstructive Biliary Disease Cholestasis Extrahepatic
Gallbladder Disease	Gallbladder Diseases Gall Bladder Gall Bladder Diseases Abnormal Gallbladder Function
Cholestasis, Progressive Familial Intrahepatic, 3	PFIC3 Cholestasis, Progressive Familial Intrahepatic 3 Mdr3 Deficiency Progressive Familial Intrahepatic Cholestasis Type 3 Progressive Familial Intrahepatic Cholestasis 3 Progressive Familial Intrahepatic Cholestasis With Elevated Serum Gamma-Glutamyltransferase Cholestasis, Progressive Familial Intrahepatic, With Elevated Serum Gamma-Glutamyltransferase Progressive Familial Intrahepatic Cholestasis With Elevated Serum Gama-Glutamyltransferase Cholestasis, Intrahepatic, Familial, Progressive, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125996	NR1H4 activator 1	Agonist	/	Unkown
HY-RS09531	NR1H4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09532	Nr1h4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09533	Nr1h4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-182395	DM175	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NR1H4	VGNC	VGNC:32232
Canis familiaris	NR1H4	VGNC	VGNC:43944
Felis catus	NR1H4	VGNC	VGNC:68546
Rattus norvegicus	NR1H4	RGD	RGD:628831
Mus musculus	NR1H4	MGD	MGI:1352464
Macaca mulatta	NR1H4	VGNC	VGNC:75506
Others	NR1H4	NCBI