Dichloroisocyanurate sodium
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Dichloroisocyanurate sodium is a synthetic organochlorine compound belonging to triazine derivatives, and is commonly used as a disinfectant and biocide. Dichloroisocyanurate sodium can release hypochlorous acid to inactivate waterborne bacteria, viruses, helminths and protozoa, and can act as a hypochlorous acid reservoir to provide sustained biocidal protection.
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- No. CAS: 2893-78-9
- Fòrmula: C3HCl2N3NaO3
- Peso molecular:220.95
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Almacenamiento:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
Sodium dichloroisocyanurate exhibits excellent antimicrobial activity against a variety of Gram-positive bacteria, Gram-negative bacteria and fungi, and its activity is not affected by temperature or pH[1].
Sodium dichloroisocyanurate exhibits excellent disinfection activity against various microorganisms on fresh vegetables[1].
Sodium dichloroisocyanurate (30 min) eliminates all coliforms and E. coli from low-turbidity water, and reduces the viable count in raw river water by 1.8-2.8 log units[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley/Crl:CD (7 weeks old after 6 days of acclimatization; 10 males/females per exposure group, 5 males/females per recovery group)[2]
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Dosage:0.4 mg/m3; 2.0 mg/m3; 10.0 mg/m3
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Administration:whole-body inhalation; 6 hours/day, 7 days/week; 90 days; 14-day recovery (10.0 mg/m3 group only)
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Result:Exhibited signs of lung inflammation, eosinophilic granules observed in the nasal cavity, hyperplasia of mucous cells, atrophy/degeneration of the tracheal epithelium, and thickening of the walls of the alveolar ducts in high dose group.
Chemical Information
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No. CAS 2893-78-9
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Appearance Solid
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Peso molecular 220.95
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Fòrmula C3HCl2N3NaO3
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Color White to off-white
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SMILES
[Na].O=C1NC(=O)N(Cl)C(=O)N1Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvente y solubilidad
In Vitro:
DMSO : 5 mg/mL (22.63 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.5 mg/mL (2.26 mM); Clear solution
This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 0.5 mg/mL (2.26 mM); Clear solution
This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (916 KB)
- English - EN (916 KB)
- Français - FR (916 KB)
- Deutsch - DE (916 KB)
- Norwegian - NO (916 KB)
- Español - ES (916 KB)
- Swedish - SV (916 KB)
- Italian - IT (916 KB)
- Korean - KR (916 KB)
- Portuguese - PT (916 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Clasen T, et al. Sodium dichloroisocyanurate (NaDCC) tablets as an alternative to sodium hypochlorite for the routine treatment of drinking water at the household level. Int J Hyg Environ Health. 2006;209(2):173-181. [Content Brief]
[2]. Park CM, et al. Sodium dichloroisocyanurate toxicity in rats during a 90-day inhalation toxicity study. Toxicol Appl Pharmacol. 2022;456:116279. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5259 mL | 22.6296 mL | 45.2591 mL | 113.1478 mL |
| 5 mM | 0.9052 mL | 4.5259 mL | 9.0518 mL | 22.6296 mL | |
| 10 mM | 0.4526 mL | 2.2630 mL | 4.5259 mL | 11.3148 mL | |
| 15 mM | 0.3017 mL | 1.5086 mL | 3.0173 mL | 7.5432 mL | |
| 20 mM | 0.2263 mL | 1.1315 mL | 2.2630 mL | 5.6574 mL |
Dichloroisocyanurate sodium Related Classifications
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