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Cat. No.: HY-148617

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ALDH2 modulator 1

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ALDH2 modulator 1 is a potent and orally active aldehyde dehydrogenase-2 (ALDH2) modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice.

For research use only. We do not sell to patients.

Purity: 99.25%
CAS No.: 1629615-99-1
Formula: C₁₈H₁₈ClFN₂O₃
Molecular Weight:364.80

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ALDH2 modulator 1 Chemical Structure

CAS No.: 1629615-99-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ALDH2 modulator 1 is a potent and orally active aldehyde dehydrogenase-2 (ALDH2) modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice^[1].

IC₅₀ & Target^[1]

ALDH2

All Aldehyde Dehydrogenase (ALDH) Isoforms :

In Vivo

ALDH2 modulator 1 (compound 161) (10 mg/kg for i.v.; 40, 60 mg/kg for p.o.) reduces blood alcohol levels in mice treated with PO 5 g/kg of EtOH^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

8-9 weeks, 20-22 g, Male C57BL6 mice (treated with PO 5/kg of EtOH)^[1]
Dosage:

40, 60 mg/kg for p.o. or 10 mg/kg for i.v.
Administration:

P.o. or i.v.
Result:

Reduced blood alcohol levels in mice treated with PO 5 g/kg of EtOH.

Chemical Information

CAS No. 1629615-99-1
Appearance Solid
Molecular Weight 364.80
Formula C₁₈H₁₈ClFN₂O₃
SMILES

O=C(C1=C(C=CN=C1OCC2CC2)Cl)NCC3=CC=C(C(F)=C3)OC
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wenjin Yang, et al. Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof. WO2014160185A2.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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ALDH2 modulator 1

All Aldehyde Dehydrogenase (ALDH) Isoforms