BTN2A1 - butyrophilin subfamily 2 member A1 Gene

Also Known as BTF1; BT2.1; BTN2.1; DJ3E1.1; BK14H9.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11120

About BTN2A1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,457,955-26,476,622 (from NCBI)

This gene has 7 transcripts (splice variants), 1855 orthologues and 15 paralogues. Ubiquitous expression in spleen (RPKM 14.7), appendix (RPKM 11.4) and 25 other tissues.

Summary

This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the juxta-telomeric region of the major histocompatibility complex on chromosome 6. A pseudogene of this gene has been identified in this cluster. The encoded protein is an integral plasma membrane protein involved in lipid, fatty-acid, and sterol metabolism. Alterations in this gene may be associated with several disease states including metabolic syndrome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

BTN2A1 Products (4)

mRNA Protein Name
NM_001197233.3 NP_001184162.1 butyrophilin subfamily 2 member A1 isoform 3
NM_001197234.3 NP_001184163.1 butyrophilin subfamily 2 member A1 isoform 4 precursor
NM_007049.5 NP_008980.1 butyrophilin subfamily 2 member A1 isoform 1 precursor
NM_078476.4 NP_510961.1 butyrophilin subfamily 2 member A1 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTN2A1 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (34 - 129)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (155 - 229)

PRY

PRY: SPRY-associated domain (330 - 381)

SPRY

SPRY: SPRY domain (383 - 493)

  • 0
  • 100
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  • 500
  • 527 a.a.
Protein Preferred Names Protein Names

butyrophilin subfamily 2 member A1

Recombinant BTN2A1 Proteins

Cat. No. Product Name Accession Purity
HY-P7681 BTN2A1 Protein, Human (HEK293, His) Q7KYR7-2 (Q29-A248) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78564 BTN2A1 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q7KYR7-2 (Q29-A248) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-186052 4-M-HMBPP / Unkown
HY-RS01671 BTN2A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BTN2A1 MGD MGI:3606486
Others BTN2A1 NCBI