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Cat. No.: HY-186052

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4-M-HMBPP

4-M-HMBPP is a weak agonist for Vγ9Vδ2 T cell activation and a potent competitive inhibitor of HMBPP. 4-M-HMBPP binds to BTN3A1 with high affinity (K_D: 26.2 μM), but fails to induce its complex formation with BTN2A1. 4-M-HMBPP can be used in studies on γδ T cell activation.

For research use only. We do not sell to patients.

Formula: C₁₂H₁₅F₃O₈P₂
Molecular Weight:406.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

4-M-HMBPP Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	EC₅₀	10 μM Compound: 6e	Effect on IFN-gamma release in human PBMC incubated for 48 hrs by ELISA Effect on IFN-gamma release in human PBMC incubated for 48 hrs by ELISA	[PMID: 39029338]

In Vitro

4-M-HMBPP (Compound 6e) (100 μM; 24 h) does not significantly activate the interaction between BTN3A1 and BTN2A1 in K562 cells^[1].
4-M-HMBPP (0.001-100 μM; stimulated for 3 days, cultured for 11 days) does not induce the proliferation of Vγ9Vδ2 T cells in human peripheral blood mononuclear cells (PBMCs)^[1].
4-M-HMBPP (0.01-100 μM; 48 h) inhibits HMBPP-induced IFNγ release in human PBMCs, with an IC₅₀ of 0.63 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 406.19
Formula C₁₂H₁₅F₃O₈P₂
SMILES

O=P(OP(O)(O)=O)(OC/C=C(CC1=CC=C(C=C1)C(F)(F)F)/CO)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Singh R, et al. Synthesis and evaluation of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate analogs as competitive partial agonists of butyrophilin 3A1. Eur J Med Chem. 2024;276:116673. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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