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LRIG1 - leucine rich repeats and immunoglobulin like domains 1 Gene

Also Known as LIG1; LIG-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26018

About LRIG1

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:66,378,797-66,501,121 (from NCBI)

This gene has 9 transcripts (splice variants), 203 orthologues and 22 paralogues. Ubiquitous expression in brain (RPKM 61.1), fat (RPKM 28.0) and 23 other tissues.

Summary

Predicted to act upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

LRIG1 Products (7)

mRNA	Protein	Name
NM_001377344.1	NP_001364273.1	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 2 precursor
NM_001377345.1	NP_001364274.1	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3
NM_001377346.1	NP_001364275.1	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3
NM_001377347.1	NP_001364276.1	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 4
NM_001377348.1	NP_001364277.1	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 5
NM_001377349.1	NP_001364278.1	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 6
NM_015541.3	NP_056356.2	leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15282549	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRIG1 Protein Structure

LRR_8

LRRCT

I-set

0
200
400
600
800
1000
1093 a.a.

Protein Preferred Names	Protein Names
leucine-rich repeats and immunoglobulin-like domains protein 1	leucine-rich repeat protein LRIG1

LRIG1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LRIG1	Q96JA1	EGFR	Homo sapiens	P00533	Anti Tag CoIP	15282549
Intra	LRIG1	Q96JA1	EGFR	Homo sapiens	P00533	Anti Bait CoIP	18542056
Intra	LRIG1	Q96JA1	EGFR	Homo sapiens	P00533	Anti Bait CoIP	15282549
Intra	LRIG1	Q96JA1	EGFR	Homo sapiens	P00533	Anti Tag CoIP	15345710
Intra	LRIG1	Q96JA1	CBL	Homo sapiens	P22681	Pull Down	15282549
Intra	LRIG1	Q96JA1	CBL	Homo sapiens	P22681	Anti Tag CoIP	15282549
Intra	LRIG1	Q96JA1	ERBB2	Homo sapiens	P04626	Anti Tag CoIP	15282549
Intra	LRIG1	Q96JA1	ERBB2	Homo sapiens	P04626	Anti Tag CoIP	15345710
Intra	LRIG1	Q96JA1	ERBB2	Homo sapiens	P04626	Anti Bait CoIP	23723069
Intra	LRIG1	Q96JA1	ERBB2	Homo sapiens	P04626	IF	15345710
Intra	LRIG1	Q96JA1	ERBB3	Homo sapiens	P21860	Anti Tag CoIP	15282549
Intra	LRIG1	Q96JA1	ERBB4	Homo sapiens	Q15303	Anti Tag CoIP	15345710
Intra	LRIG1	Q96JA1	ERBB4	Homo sapiens	Q15303	Anti Tag CoIP	15282549
Intra	LRIG1	Q96JA1	LRIG3	Homo sapiens	Q6UXM1	Anti Bait CoIP	23723069
Intra	LRIG1	Q96JA1	LRIG3	Homo sapiens	Q6UXM1	Anti Tag CoIP	33961781
Intra	LRIG1	Q96JA1	LRIG3	Homo sapiens	Q6UXM1	Anti Tag CoIP	23723069

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRIG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77988	LRIG1 Protein, Human (HEK293, His)	Q96JA1-1 (A35-S779)	≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases	Alias
Urofacial Syndrome 1	Urofacial Syndrome Ochoa Syndrome Hydronephrosis With Peculiar Facial Expression Ufs Inverted Smile And Occult Neuropathic Bladder Partial Facial Palsy With Urinary Abnormalities UFS1 Urofacial Ochoa'S Syndrome Urofacial Syndrome Type 1 Facial Palsy, Partial, With Urinary Abnormalities Hydronephrosis-Inverted Smile Inverted Smile-Neurogenic Bladder Hydronephrosis-Inverted Smile Syndrome Inverted Smile-Neurogenic Bladder Syndrome Partial Facial Palsy Partial With Urinary Abnormalities Urologic Diseases
Sebaceous Adenoma	Adenoma Of The Sebaceous Gland Skin Appendage Sebaceous Adenoma
Sebaceous Gland Neoplasm	Sebaceous Gland Neoplasms Sebaceous Neoplasm
Hair Follicle Neoplasm	Hair Matrix Neoplasm Hair Matrix Tumour
Colonic Benign Neoplasm	Colon Neoplasm Colonic Mass Colonic Tumor Neoplasm Of Colon Neoplasm Of The Colon Colonic Neoplasms Colon Cancer Colon Carcinoma Nos Colonic Cancer Metastatic Colon Cancer Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07787	LRIG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19215	Lrig1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25704	Lrig1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992369	HMBD-002	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRIG1	RGD	RGD:1306788
Macaca mulatta	LRIG1	VGNC	VGNC:84156
Canis familiaris	LRIG1	VGNC	VGNC:42767
Bos taurus	LRIG1	VGNC	VGNC:30982
Felis catus	LRIG1	VGNC	VGNC:80612
Mus musculus	LRIG1	MGD	MGI:107935
Others	LRIG1	NCBI