NTN4 - netrin 4 Gene

Also Known as PRO3091

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 59277

About NTN4

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:95,657,807-95,791,155 (from NCBI)

This gene has 8 transcripts (splice variants), 248 orthologues and 27 paralogues. Broad expression in spleen (RPKM 88.7), kidney (RPKM 62.7) and 20 other tissues.

Summary

This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

NTN4 Products (4)

mRNA Protein Name
NM_001329700.2 NP_001316629.1 netrin-4 isoform 2 precursor
NM_001329701.2 NP_001316630.1 netrin-4 isoform 3
NM_001329702.2 NP_001316631.1 netrin-4 isoform 3
NM_021229.4 NP_067052.2 netrin-4 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTN4 Protein Structure

Laminin_N

Laminin_N: Laminin N-terminal (Domain VI) (34 - 260)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (262 - 318)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (332 - 383)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (395 - 443)

NTR

NTR: UNC-6/NTR/C345C module (518 - 621)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 628 a.a.
Protein Preferred Names Protein Names

netrin-4

  • beta-netrin

NTN4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NTN4 Q9HB63 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
NTN4 Q9HB63 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
NTN4 Q9HB63 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
NTN4 Q9HB63 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
NTN4 Q9HB63 CASK Homo sapiens O14936-4
Y2H Array
32296183
Intra
NTN4 Q9HB63 CASK Homo sapiens O14936-4
Y2H Prey Pooling
32296183
Intra
NTN4 Q9HB63 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra
NTN4 Q9HB63 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra
NTN4 Q9HB63 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
NTN4 Q9HB63 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
NTN4 Q9HB63 KRTAP21-2 Homo sapiens Q3LI59
Y2H Array
32296183
Intra
NTN4 Q9HB63 KRTAP21-2 Homo sapiens Q3LI59
Y2H Prey Pooling
32296183
Intra
NTN4 Q9HB63 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
NTN4 Q9HB63 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
NTN4 Q9HB63 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
NTN4 Q9HB63 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
NTN4 Q9HB63 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
NTN4 Q9HB63 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
NTN4 Q9HB63 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
NTN4 Q9HB63 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
NTN4 Q9HB63 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
NTN4 Q9HB63 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
NTN4 Q9HB63 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08488 MLF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09623 NTN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17641 Ntn4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24101 Ntn4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NTN4 VGNC VGNC:63904
Rattus norvegicus NTN4 RGD RGD:1565947
Canis familiaris NTN4 VGNC VGNC:44009
Bos taurus NTN4 VGNC VGNC:32306
Macaca mulatta NTN4 VGNC VGNC:75399
Mus musculus NTN4 MGD MGI:1888978
Others NTN4 NCBI